Evidence map›Paper›PMID 40783646›Full record

ArticleScientific reports2025

Associations of maternal neighborhood and trauma-related stressors with mitochondrial DNA copy number and telomere length in maternal and cord blood.

Ixel Hernandez-Castro, Sheryl L Rifas-Shiman, Danielle M Panelli, Anna R Smith, Li Yi, Izzuddin M Aris, Henning Tiemeier, Mandy B Belfort, Farah Qureshi, Diane R Gold and 3 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

13 authors.

Ixel Hernandez-CastroDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, 94305, USA.
Sheryl L Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Danielle M PanelliDivision of Maternal-Fetal Medicine and Obstetrics, Department of Obstetrics and Gynecology, Stanford University, Stanford, CA, USA.
Anna R SmithDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, 94305, USA.
Li YiDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Izzuddin M ArisDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Henning TiemeierDepartment of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mandy B BelfortDepartment of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA.
Farah QureshiDepartment of Population, Family and Reproductive, Health Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Diane R GoldChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Andres CardenasDepartment of Epidemiology and Population Health, Stanford School of Medicine, Stanford, CA, 94305, USA. andresca@stanford.edu.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
NIEHS NIH HHS P30 ES000002Propel Fellowship StanfordU.S. National Institutes of Health R01ES031259, UG3 OD023286, P30-ES000002, U2CES026561, R01HD034568, R24ES030894
6 · The paper itself

Abstract

Neighborhood and individual-level trauma-related stressors during pregnancy can increase oxidative stress, potentially altering cellular disease pathway biomarkers such as mitochondrial DNA copy number (mtDNAcn) and telomere length (TL). However, the biological mechanisms linking early-life stressors to long-term health outcomes remain understudied. In a subset of Project Viva participants (n = 415-917), we evaluated associations of neighborhood and individual-level stressors with mean relative mtDNAcn and TL measured in first trimester maternal blood and cord blood. Neighborhood stressors during pregnancy were assessed using the Child Opportunity Index (COI) and Social Vulnerability Index (SVI). Trauma-related stressors were measured using the Personal Safety Questionnaire (PSQ), administered mid-pregnancy, and maternal Adverse Childhood Experiences (ACEs), reported during a mid-life follow-up. In multivariable linear regression analysis, residence in a very high versus very low opportunity neighborhood was associated with lower maternal mtDNAcn ([Formula: see text]= - 0.09, 95% confidence interval (CI) - 0.17, - 0.02), while residence in a very high versus very low vulnerability area was associated with higher maternal mtDNAcn ([Formula: see text]= 0.06, 95% CI 0.01, 0.12). Additionally, residence in moderate versus very low opportunity neighborhoods was associated with longer cord blood TL ([Formula: see text]= 0.39, 95% CI 0.0002, 0.78), but associations were attenuated after cell-type adjustment. Our findings suggest that prenatal neighborhood stressors are associated with increased maternal mtDNAcn and neighborhood opportunity is associated with longer fetal TL, indicating possible links to biological pathways related to oxidative stress and cellular aging.

Indexed as

DNA Copy Number VariationsDNA, MitochondrialFetal BloodResidence CharacteristicsStress, PsychologicalTelomereTelomere HomeostasisAdultAdverse Childhood ExperiencesFemaleHumansOxidative StressPregnancyDNA, MitochondrialFetal healthMaternal healthMitochondrial DNA copy numberNeighborhood stressorsPsychosocial stressTelomere length

Identifiers

PMID40783646
PMCPMC12335485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.