ArticleBiomedical engineering online2025
Cholesterol homeostasis and pathway enrichment in post-revascularization recovery.
Article in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- AVSeg-XAI: Deep learning framework for A/V segmentation with vascular features reveals retinal oculomics as biomarker for cardiovascular disease.BioData mining · 2026Article
- Regulation of lipid droplets accumulation by the Hippo-YAP/COX2 signaling pathway in neomycin-induced ototoxicity.Cell death discovery · 2026Article
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3 authors.
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Abstract
backgroundHeart revascularization is a critical intervention for restoring myocardial perfusion in patients with ischemic cardiovascular disease. While the procedure alleviates ischemia, it also triggers systemic metabolic and transcriptional changes, particularly in lipid metabolism.
methodsIn this pilot study, we utilized RNA-seq data from 4 revascularized patients and 5 control participants from the Qatar Biobank (QBB) to investigate the effects of revascularization on cholesterol biosynthesis and metabolic pathways. Differential gene expression analysis was performed to identify key regulatory genes, followed by pathway enrichment and Gene Ontology analyses.
resultsThirteen differentially expressed genes, including ABCG1, EBP, and LPCAT3, were identified as potentially involved in cholesterol regulation, lipid remodeling, and sterol metabolism. Notably, ABCG1, EBP, and LPCAT3 showed significant downregulation. Correlation analysis revealed strong associations between gene expression and clinical parameters, with ABCG1 expression negatively correlating with triglyceride levels (r = - 0.89, p = 0.001).
conclusionThis exploratory study provides preliminary evidence that heart revascularization may affect cholesterol-related metabolic pathways. While the small sample size (n = 4 revascularized patients) limits generalizability, these findings generate important hypotheses regarding post-revascularization metabolic adaptation and establish a foundation for larger validation studies. Future research with expanded cohorts is essential to confirm these preliminary observations and their therapeutic implications.
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