ArticleBMC gastroenterology2025
Global, regional, and national burden of colorectal cancer in the elderly (aged > 60 years): a comprehensive analysis across 204 countries and territories (1990-2021).
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Prognostic value of D3 lymph node dissection and nutritional status in colorectal cancer patients aged 80 years and older.International journal of colorectal disease · 2026Article
- The Burden and Risk Factors of Colorectal Cancer in Older Adults From 2010 to 2021: A Systematic Analysis for the Global Burden of Disease Study 2021.Clinical and translational gastroenterology · 2026Article
- Factors associated with functional status among older adults with colorectal cancer receiving chemotherapy in Thailand: A cross-sectional study.Belitung nursing journal · 2026Article
- Article
- Impact of age on short-term outcomes and oncologic prognosis after radical surgery for colorectal cancer over 60.International journal of colorectal disease · 2025Article
- Robot-Assisted Colorectal Cancer Surgery Mitigates Early Postoperative Immunosuppression and Angiogenesis.International journal of molecular sciences · 2025Article
- TSC1 deficiency drives immune evasion in colorectal cancer via mTORC1-mediated dysregulation of PD-L1 sialylation.Frontiers in immunology · 2025Article
- Human papillomavirus prevalence, genotype distribution, risk factors, and cervical pathology association in women aged 50 years and older: a retrospective cross-sectional study in Xinjiang, China.Frontiers in oncology · 2025Article
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5 authors.
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Abstract
backgroundColorectal Cancer (CRC) is highly prevalent among the elderly (Aged > 60 Years). Investigating the global epidemiological trends of colorectal cancer in elderly patients can aid in developing targeted prevention and control measures.
methodsThe epidemiological data on CRC in the elderly were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, encompassing annual estimates from 1990 to 2021. The acquired metrics included incidence, prevalence, deaths, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs). We analyzed temporal trends of these diverse disease burden indicators for CRC in the elderly population. Furthermore, the Bayesian age-period-cohort (BAPC) model was employed to project future the elderly CRC burden at both national and regional levels.
resultsIn 2021, the global elderly CRC had a total incidence of 1,617,011 (1,447,212-1,754,348), with an age-standardized incidence rate (ASIR) of 149.16 (133.11-161.91). The total prevalence was 8,079,970 (7,332,761-8,727,386), with an age-standardized prevalence rate (ASPR) of 737.47 (668.26-796.77). Total deaths numbered 827,471 (736,233-897,443), with an age-standardized death rate (ASDR) of 77.51 (68.71-84.13). Total DALYs were 15,347,705 (13,913,323- 16,592,781), with an age-standardized DALYs rate of 1407.18 (1272.56-1522.03). Total YLDs were 764,739 (562,029-991,490), with an age-standardized YLDs rate of 70.16 (51.55-90.93). Total YLLs were 14,582,966 (13,217,174- 15,764,048), with an age-standardized YLLs rate of 1337.02 (1208.87-1445.89). From 1990 to 2021, the AAPC of ASIR for global elderly CRC was 0.13 (0.12 to 0.15), the AAPC of ASPR for global elderly CRC was 0.63 (0.61 to 0.65), the AAPC of ASDR for global elderly CRC was - 0.72 (- 0.74 to- 0.69), the AAPC of Age-standardized DALYs rate for global elderly CRC was - 0.72 (- 0.73 to- 0.69), the AAPC of Age-standardized YLDs rate for global elderly CRC was 0.35 (0.33 to 0.37), the AAPC of Age-standardized YLLs rate for global elderly CRC was - 0.76 (- 0.78 to- 0.74). Projections based on the Bayesian Age-Period-Cohort model indicate that elderly CRC would continue to impose a substantial disease burden through 2025.
conclusionIn 2021, the global burden of CRC among the elderly remained substantial. Projections to 2050 indicate that the burden of elderly CRC would continue to rise. To mitigate this burden, global efforts must prioritize early detection through expanded screening programs, improved access to treatment, and enhanced public health strategies, particularly in regions with limited healthcare infrastructure.
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