Evidence map›Paper›PMID 40783475›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Risk factors for perinatal and neonatal mortality in cases with congenital anomalies of the kidney and urinary tract: a nested cohort study.

Rodrigo R Arantes, Marcos B Aguiar, Keyla C C M S Cunha, Arthur A Amaral, José Renato O Melo, Beatriz Chaves C Vieira, Enrico A Colosimo, Eduardo A Oliveira, Ana Cristina Simoes E Silva

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Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rodrigo R ArantesDivision of Genetics, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.ORCID 0000-0002-5041-1102
Marcos B AguiarDivision of Genetics, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.ORCID 0000-0003-0497-5262
Keyla C C M S CunhaDepartment of Pediatrics, Faculty of Medicine, UFMG, Belo Horizonte, Brazil.ORCID 0000-0002-4049-4645
Arthur A AmaralDepartment of Pediatrics, Faculty of Medicine, UFMG, Belo Horizonte, Brazil.ORCID 0000-0002-7224-3197
José Renato O MeloDepartment of Pediatrics, Faculty of Medicine, UFMG, Belo Horizonte, Brazil.ORCID 0009-0005-8233-6089
Beatriz Chaves C VieiraDepartment of Pediatrics, Faculty of Medicine, UFMG, Belo Horizonte, Brazil.ORCID 0009-0001-7195-9898
Enrico A ColosimoDepartment of Statistics, UFMG, Belo Horizonte, Brazil.ORCID 0000-0001-8705-4674
Eduardo A OliveiraUnit of Pediatric Nephrourology, Department of Pediatrics, Faculty of Medicine, UFMG, Alfredo Balena Avenue, 190, 2Nd Floor, Room # 281, Belo Horizonte, MG, 30130-100, Brazil.ORCID 0000-0002-5642-7164
Ana Cristina Simoes E SilvaUnit of Pediatric Nephrourology, Department of Pediatrics, Faculty of Medicine, UFMG, Alfredo Balena Avenue, 190, 2Nd Floor, Room # 281, Belo Horizonte, MG, 30130-100, Brazil. acssilva@hotmail.com.ORCID 0000-0001-9222-3882

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304496/2023-5
6 · The paper itself

Abstract

backgroundWe aimed to investigate predictive factors associated with perinatal and neonatal mortality in cases with congenital anomalies of the kidney and urinary tract (CAKUT).

methodsThis study included a cohort of neonates with CAKUT born at a tertiary hospital between 1996 and 2021. Controls were matched with CAKUT cases by sex, time, and place of birth at a ratio of approximately 2:1. The covariates included in the analysis were sex, gestational age, birth weight, neonatal classification, and birth order. CAKUT was categorized into four phenotypes: urinary tract dilatation, lower urinary tract obstruction (LUTO), cystic diseases, and agenesis/hypodysplasia. The primary outcome was perinatal and neonatal mortality. Survival analysis was performed using the Cox proportional hazards model.

results857 cases and 1,755 controls were included in the analysis. The overall early mortality rate was 7.2%. After controlling for confounding factors, CAKUT cases exhibited a higher risk of perinatal and neonatal mortality than controls (hazard ratio [HR], 25.1; 95%CI, 14.0-45.2). The following covariates were independently associated with mortality: prematurity (HR, 1.7; 95%CI, 1.2-2.5), LBW (HR, 2.4; 95%CI, 1.6-2.5), VLBW (HR, 2.9; 95%CI, 1.1-1.7), oligohydramnios (HR, 3.2; 95%CI, 2.2-4.8), cystic diseases (HR, 3.8; 95%CI, 2.3-6.4), LUTO (HR, 5.1; 95%CI, 3.0-8.5), kidney agenesis/hypodysplasia (HR, 5.1; 95%CI, 2.9-8.7), and extra-renal malformations (HR, 2.6; 95% CI, 1.7-3.9).

conclusionsCAKUT was associated with elevated stillbirth and neonatal mortality rates compared with controls. Prematurity, LBW, oligohydramnios, extra-renal malformations, and specific CAKUT phenotypes with kidney involvement were associated with increased mortality risk.

Indexed as

KidneyPerinatal MortalityUrinary TractUrogenital AbnormalitiesVesico-Ureteral RefluxBirth OrderBirth WeightBrazilCase-Control StudiesFemaleGestational AgeHumansInfant, NewbornMalePregnancyProportional Hazards ModelsCongenital anomalies of the kidney and urinary tractLower urinary tract obstructionNeonatal mortalityUrinary tract dilation

Identifiers

PMID40783475

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.