ReviewActa neurologica Belgica2025
Role of hippocampus in epileptogenesis: new insights in the cross-talks between the underlying mechanisms.
Review in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Epileptogenesis After Stroke: Current Insights Into Molecular and Structural Mechanisms.Cureus · 2026Review
- Anticonvulsant role of nitric oxide synthase inhibitors in epilepsy (Review).Medicine internationalReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a component of the limbic system, the hippocampal region, one of the deep structures of the medial temporal lobe, is a complex structure involved in a wide range of cognitive processes, including declarative memory, spatial memory, and emotional reactions. The subiculum, the dentate gyrus (DG), and the cornu of Ammonis (CA)-which includes the four subfields CA4, CA3, CA2, and CA1-make up the hippocampus. The hippocampus is known to have the lowest seizure threshold. Therefore, the hippocampus is relatively more prone to seizures, and plays a significant role in epilepsy. Also, it has been reported that seizures can result in abnormal hippocampal neurogenesis and malfunctioning circuits that impair hippocampal function. Several mechanisms have been suggested for the process of epileptogenesis including gliosis, neuronal degeneration, neurotransmitter disturbances, channelopathy, neuroinflammations, and axonal plasticity. In this review, we will focus on the role of the hippocampus in the process of epileptogenesis, as well as on the morphological changes in hippocampal structure, neuronal circuits, neurotransmitters and neurosteroids in epilepsy.
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Identifiers
40783473What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.