ArticleScientific reports2025
Light discomfort thresholds under different lighting conditions in healthy subjects and dry eye patients.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A National Survey Including Data from 5986 Dry Eyes Treated with a Novel Tear Substitute Containing Ribohyal.Journal of clinical medicine · 2026Article
- Immunomodulation of the Ocular Surface in Severe Dry Eye Disease: Expert-Driven Literature Review on Treatment Strategies with Description of Representative Challenging Cases.Ophthalmology and therapy · 2026Review
- Quantitative assessment of light discomfort thresholds in a patient with photoallodynia treated with topical naltrexone 0.01.American journal of ophthalmology case reports · 2026Article
- Light Discomfort Thresholds in Patients with Moderate-to-Severe Active versus Mild Non-Active Thyroid Eye Disease.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light-related visual disturbances are common symptoms among patients with dry eye disease (DED) but difficult to be evaluated in the clinical practice. This cross-sectional, multicenter, controlled study aimed at comparing light discomfort thresholds in healthy individuals and patients with DED, and to further correlate thresholds with ocular surface parameters. The Lumiz 100 device (Essilor International, Paris, France) was employed to measure light discomfort thresholds in 25 patients with DED and 25 sex- and age-matched healthy subjects under different lighting conditions: continuous warm, continuous cold and flashing warm. Participants were instructed to press a button twice to signal discomfort levels as "just perceptible" and "really disturbing". The mean of the two values was calculated for each lighting condition. DED patients exhibited lower discomfort thresholds for all measurements compared to controls (continuous warm: 2.81 ± 0.56 log10[lux] vs. 3.47 ± 0.51 log10[lux], continuous cold: 2.78 ± 0.54 log10[lux] vs. 3.48 ± 0.50 log10[lux], flashing warm: 2.54 ± 0.53 log10[lux] vs. 3.12 ± 0.69 log10[lux], all p ≤ 0.004). A significant negative correlation was found between total light sensitivity threshold and ocular discomfort symptoms in patients with DED (r=-0.499, p = 0.011). Conversely, no significant correlation was found between light thresholds and the other ocular surface parameters. These findings show that DED patients have a higher light sensitivity than healthy subjects.
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