Evidence map›Paper›PMID 40783458›Full record

SynthesisDigestive diseases and sciences2026

Monitoring Liver and Spleen Stiffness Changes May Predict Clinical Response to Non-selective B-Blockers in Portal Hypertension: A Systematic Review and Meta-Analysis.

Maria Tambaki, Antonia Neonaki, Vasileios Lekakis, Margarita Papatheodoridi, Dimitrios S Karagiannakis

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Tambaki1st Academic Department of Gastroenterology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Antonia Neonaki1st Academic Department of Gastroenterology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Vasileios Lekakis1st Academic Department of Gastroenterology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Margarita Papatheodoridi1st Academic Department of Gastroenterology, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios S Karagiannakis4th Department of Internal Medicine, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, Rimini 1 Street, Haidari, 12462, Athens, Greece. dkarag@med.uoa.gr.ORCID http://orcid.org/0000-0003-0082-634X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment with non-selective b-blockers (NSBBs) is the mainstay of pharmacological management of portal hypertension (PH), but monitoring treatment response is not well standardized. Liver stiffness (LSM) and spleen stiffness measurement (SSM) changes have been used as non-invasive biomarkers of PH and are associated with disease progression and liver-related events. This systematic review examined LSM and SSM changes (ΔLSM, ΔSSM) in patients receiving NSBBs and their ability to predict treatment response.

methodsA literature search was performed to identify all published studies with patients with PH receiving NSBBs and monitoring with LSM and/or SSM. Pooled proportions, 95% confidence intervals (CI), and prediction intervals (PI) were calculated. The results of primary studies with varying diagnostic thresholds were plotted with a Summarized Receiver Operating Characteristic curve (SROC), and areas under the SROCs were compared.

resultsThe meta-analysis included eight studies and 445 patients with PH. The mean LSM percentage reduction was 12% (95%CI - 16, - 8; I

conclusionBoth LSM and SSM decrease significantly after NSBB treatment in patients with PH. However, ΔSSM appears to be superior to ΔLSM in predicting an effective treatment response.

Indexed as

Adrenergic beta-AntagonistsHypertension, PortalLiverSpleenElasticity Imaging TechniquesHumansPredictive Value of TestsTreatment OutcomeAdrenergic beta-AntagonistsLiver CirrhosisLiver StiffnessNon-selective b-blockersPortal HypertensionSpleen Stiffness

Identifiers

PMID40783458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.