Evidence map›Paper›PMID 40783382›Full record

ArticleNature communications2025

Gastrointestinal neuroprosthesis for motility and metabolic neuromodulation.

Shriya Srinivasan, Marc-Joseph Antonini, Amro Alshareef, Atharva Sahasrabudhe, Josh Jenkins, Keiko Ishida, Johannes Kuosmanen, Alison Hayward, Seokkee Min, Robert Langer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. On the horizon in biomedical engineering.Nature biomedical engineering · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shriya Srinivasan *Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2508-1324
Marc-Joseph Antonini *Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9774-1483
Amro AlshareefDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8813-2531
Atharva SahasrabudheMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2615-2470
Josh JenkinsDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-7698-9888
Keiko IshidaDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Johannes KuosmanenDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Alison HaywardDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Seokkee MinDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7308-6840
Robert LangerDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4255-0492
Polina AnikeevaMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. anikeeva@mit.edu.ORCID http://orcid.org/0000-0001-6495-5197
Giovanni TraversoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.ORCID http://orcid.org/0000-0001-7851-4077

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal (GI) dysmotility and associated conditions affect over 20% of population, yet pharmacological, behavioural, and surgical interventions offer limited therapeutic efficacy. Targeted electrical stimulation addressing underlying neuromuscular pathology stands to transform our ability to treat dysmotility. Here, we developed a closed-loop GI neuroprosthesis which activates or relaxes GI tract musculature through electrochemical stimulation in response to sensed food stimuli. We additionally describe a tool supporting minimally invasive endoscopically guided implantation that can penetrate the mucosa, accurately localize the submucosa, and safely deploy this device to directly interface with the enteric nervous system. The neuroprosthesis enables generation of coordinated peristaltic waves, significantly increasing the motility rate in a swine model of oesophageal and stomach dysmotility (p < 0.05, student's t-test). Further, by directly modulating the myenteric plexus and thus mimicking meal ingestion, we induce peristalsis in a fasted state and achieve a metabolic response commensurate with a fed or satiated state. This neuroprosthesis and implantation platform expand opportunities in fundamental studies and treatments of metabolic and neuromuscular pathologies affecting the GI tract.

Indexed as

Electric Stimulation TherapyGastrointestinal MotilityGastrointestinal TractNeural ProsthesesAnimalsElectric StimulationEnteric Nervous SystemEsophagusFemaleMyenteric PlexusPeristalsisSwine

Identifiers

PMID40783382
PMCPMC12335536

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.