Evidence map›Paper›PMID 40783350›Full record

ReviewThe Lancet. Digital health2025

Value of artificial intelligence in neuro-oncology.

Sebastian Voigtlaender, Thomas A Nelson, Philipp Karschnia, Eugene J Vaios, Michelle M Kim, Philipp Lohmann, Norbert Galldiks, Mariella G Filbin, Shekoofeh Azizi, Vivek Natarajan and 3 more

Abstract readReview
In one paragraph

Review in The Lancet. Digital health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sebastian VoigtlaenderVirtual Diagnostics Unit, QuantCo, Cambridge, MA, USA; Max Planck Institute for Biological Cybernetics, Systems Neuroscience Division, Tübingen, Germany.
Thomas A NelsonDivision of Neuro-Oncology, Mass General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Clinical Neurology and Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Philipp KarschniaDivision of Neuro-Oncology, Mass General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurosurgery, Ludwig-Maximilians-University and University Hospital Munich, Munich, Germany.
Eugene J VaiosDepartment of Radiation Oncology, Duke University Medical Center, Durham, NC, USA.
Michelle M KimDepartment of Radiation Oncology, University of Michigan Hospital, Ann Arbor, MI, USA.
Philipp LohmannInstitute of Neuroscience and Medicine (INM-3, INM-4), Research Center Juelich (FZJ), Juelich, Germany; Department of Nuclear Medicine, RWTH Aachen University Hospital, Aachen, Germany.
Norbert GalldiksInstitute of Neuroscience and Medicine (INM-3, INM-4), Research Center Juelich (FZJ), Juelich, Germany; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Mariella G FilbinDepartment of Pediatric Oncology, Dana-Farber Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shekoofeh AziziGoogle DeepMind, Toronto, ON, Canada.
Vivek NatarajanGoogle Research, Mountain View, CA, USA.
Michelle MonjeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Jorg DietrichDivision of Neuro-Oncology, Mass General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Sebastian F WinterDivision of Neuro-Oncology, Mass General Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: sfwinter@mgh.harvard.edu.

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8M
Targeting the Vasular SystemP50CA165962 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Tracy T Batchelor · 2013 to 2026
$33.5M
Neuronal Regulation of Low-Grade GliomagenesisR01CA258384 · NCI · STANFORD UNIVERSITY · PI David H Gutmann, Michelle Monje-Deisseroth · 2022 to 2026
$3.1M
Duke Radiation Oncology and Radiology Stimulating Access to Research in ResidencyR38CA245204 · NCI · DUKE UNIVERSITY · PI FLOYD, SCOTT R · 2020 to 2023
$1.4M
Dr. Kim R50 Research Specialist Clinician 2022R50CA276015 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michelle Miran Kim · 2023 to 2026
$687k
Cell-Free DNA Methylation Patterns as a Biomarker for Tumor Biology and Clinical Outcomes for Glioblastoma PatientsK38CA292995 · NCI · DUKE UNIVERSITY · PI Eugene Vaios · 2024 to 2026
$276k
NCI NIH HHS K38 CA292995NCI NIH HHS P30 CA014236NCI NIH HHS P50 CA165962NCI NIH HHS R01 CA258384NCI NIH HHS R38 CA245204NCI NIH HHS R50 CA276015
6 · The paper itself

Abstract

CNS cancers are complex, difficult-to-treat malignancies that remain insufficiently understood and mostly incurable, despite decades of research efforts. Artificial intelligence (AI) is poised to reshape neuro-oncological practice and research, driving advances in medical image analysis, neuro-molecular-genetic characterisation, biomarker discovery, therapeutic target identification, tailored management strategies, and neurorehabilitation. This Review examines key opportunities and challenges associated with AI applications along the neuro-oncological care trajectory. We highlight emerging trends in foundation models, biophysical modelling, synthetic data, and drug development and discuss regulatory, operational, and ethical hurdles across data, translation, and implementation gaps. Near-term clinical translation depends on scaling validated AI solutions for well defined clinical tasks. In contrast, more experimental AI solutions offer broader potential but require technical refinement and resolution of data and regulatory challenges. Addressing both general and neuro-oncology-specific issues is essential to unlock the full potential of AI and ensure its responsible, effective, and needs-based integration into neuro-oncological practice.

Identifiers

PMID40783350
PMCPMC12338051

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.