Evidence map›Paper›PMID 40783167›Full record

ArticleFertility and sterility2026

A prospective study of hair dyes and uterine leiomyomata incidence in the study of environment, lifestyle, and fibroids.

Samantha Schildroth, Symielle A Gaston, Quaker E Harmon, Chandra L Jackson, Amelia K Wesselink, Ganesa Wegienka, Donna D Baird, Lauren A Wise

Abstract read
In one paragraph

Article in Fertility and sterility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samantha SchildrothDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts. Electronic address: sschildr@bu.edu.
Symielle A GastonEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Quaker E HarmonEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Chandra L JacksonEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.
Ganesa WegienkaHenry Ford Health System, Detroit, Michigan.
Donna D BairdEpidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.

Funding

Uterine LeiomyomasZIAES049013 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JUKIC, ANNE MARIE · 2009 to 2025
$14.7M
Environmental influences on fertility and reproductive healthZIAES103333 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI JUKIC, ANNE MARIE · 2019 to 2025
$7.3M
Translational Research Support CoreP30ES036084 · NIEHS · WAYNE STATE UNIVERSITY · PI Melissa A Runge-Morris · 2024 to 2026
$5.2M
Endocrine disrupting chemicals and risk of uterine fibroids: a prospective studyR01ES024749 · NIEHS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2015 to 2026
$4.8M
Environmental risk factors for uterine fibroids: a prospective ultrasound study(Supplement)R01ES028235 · NIEHS · HENRY FORD HEALTH SYSTEM · PI WEGIENKA, GANESA REBECCA, WISE, LAUREN A · 2017 to 2021
$3.3M
Intramural NIH HHS ZIA ES049013Intramural NIH HHS ZIA ES103333NIEHS NIH HHS P30 ES036084NIEHS NIH HHS R01 ES024749NIEHS NIH HHS R01 ES028235
6 · The paper itself

Abstract

objectiveTo investigate associations between hair dye use and incident uterine leiomyomata (fibroids) among Black participants from the Study of Environment, Lifestyle, and Fibroids.

designProspective cohort study. SUBJECTS: Reproductive-aged (26-39 years) individuals with an intact uterus residing in the Detroit, Michigan area (n = 868). EXPOSURE: Self-reported hair dye use (any use vs. no use) in the previous 12 months queried on structured questionnaires.

main outcome measuresFibroid incidence assessed by transvaginal ultrasounds. We fit Cox proportional hazard models to estimate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for age, time in study, educational attainment, annual household income, occupational status, body mass index, age at menarche, parity, use of progestin-only injectable contraceptives within the past 2 years, alcohol consumption, and smoking status.

resultsOne hundred and forty nine incident fibroid cases were identified over 3,458 person-years of follow-up. After adjustment for confounders, use of any hair dye product (HR = 1.44; 95% CI = 0.91, 2.26) and rinses that fade (HR = 1.98; 95% CI = 1.04, 3.79) in the previous 12 months was associated with increased fibroid risk, compared with no use, although associations were generally imprecise.

conclusionIn this cohort, use of hair dye products was modestly associated with a higher fibroid risk, which has important public health implications.

Indexed as

Hair DyesLeiomyomaLife StyleUterine NeoplasmsAdultBlack or African AmericanFemaleHumansIncidenceMichiganProportional Hazards ModelsProspective StudiesRisk FactorsHair Dyesendocrine disruptorshair dyeshair productsprospective cohortUterine neoplasms

Identifiers

PMID40783167
PMCPMC12443219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.