Evidence map›Paper›PMID 40783061›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2025

Enhanced tumor retention and therapeutic potency in radionuclide therapy using GSH-induced self-assembling peptides.

Wenyu Song, Yuan Feng, Xiaoyan Li, Jonathan W Engle, Jason C Mixdorf, Molloy C DeLuca, Sophia J Lee, Zhaoguo Lin, Ruochen Tan, Xiaoli Lan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenyu SongDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Department of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, Hubei Province, China.
Yuan FengDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, Hubei Province, China.
Xiaoyan LiDepartment of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Jonathan W EngleDepartment of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Jason C MixdorfDepartment of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Molloy C DeLucaDepartment of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Sophia J LeeDepartment of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA.
Zhaoguo LinDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, Hubei Province, China.
Ruochen TanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, Hubei Province, China.
Xiaoli LanDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, Hubei Province, China. Electronic address: LXL730724@hotmail.com.
Weibo CaiDepartment of Radiology and Department of Medical Physics, University of Wisconsin - Madison, Madison, WI 53705, USA. Electronic address: wcai@uwhealth.org.
Xiao ZhangDepartment of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China; Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, Hubei Province, China. Electronic address: zhangxiao199204@foxmail.com.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
NCI NIH HHS P30 CA014520
6 · The paper itself

Abstract

Radiolabeled small-molecule drugs hold significant potential for tumor radionuclide therapy (TRT). However, the clinical application of TRT is constrained by the rapid clearance of small molecules from tumor sites and inadequate tumoral radiation sensitivity. To address these limitations, we report an in situ strategy to consume glutathione for assembly that enhances TRT by increasing reactive oxygen species and extending therapeutic time. The probe, [

Indexed as

Copper RadioisotopesGlutathioneNeoplasmsPeptidesRadiopharmaceuticalsAnimalsCell Line, TumorFemaleHumansIntegrin alphaVbeta3MiceMice, NudePositron-Emission TomographyReactive Oxygen SpeciesTissue DistributionCopper RadioisotopesGlutathioneIntegrin alphaVbeta3PeptidesRadiopharmaceuticalsReactive Oxygen SpeciesGlutathione-responsiveIn situ self-assemblyPeptideTargeted radiotherapy

Identifiers

PMID40783061
PMCPMC12412049

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.