Evidence map›Paper›PMID 40783051›Full record

ArticleThe Journal of pediatrics2025

Radiographic Severity of Neonatal Deep Medullary Venous Thrombosis is Associated with Neurodevelopmental Impairment.

Ria Pal, Gabrielle Russo Barsh, Ingrid Luo, Hisham Dahmoush, Sarah Lee, Elizabeth Mayne

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ria PalDivision of Child Neurology, Department of Neurology, Stanford University, Palo Alto, CA. Electronic address: riapal@stanford.edu.
Gabrielle Russo BarshDivision of Child Neurology, Department of Neurology, Stanford University, Palo Alto, CA.
Ingrid LuoDepartment of Medicine, Quantitative Sciences, Stanford University, Palo Alto, CA.
Hisham DahmoushDivision of Pediatric Radiology, Department of Radiology, Stanford University, Stanford, CA.
Sarah LeeDivision of Child Neurology, Department of Neurology, Stanford University, Palo Alto, CA.
Elizabeth MayneDivision of Child Neurology, Department of Neurology, Stanford University, Palo Alto, CA; Department of Medicine, Quantitative Sciences, Stanford University, Palo Alto, CA.

Funding

Stanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0M
NCATS NIH HHS UL1 TR003142
6 · The paper itself

Abstract

objectiveTo evaluate the association between severity of brain magnetic resonance imaging (MRI) findings and neurodevelopmental impairment (NDI) among neonates with radiographically identified deep medullary vein thrombosis (DMVT) and to develop an MRI grading system to help predict clinical outcomes. STUDY

designWe conducted a retrospective cohort study of infants admitted to a single, tertiary care hospital and diagnosed as having DMVT identified by brain MRI from January 1990 to March 2023. Clinical characteristics, MRI features, and neurodevelopmental assessments were analyzed. An MRI grading system was created to categorize the severity of radiographic injury as mild, moderate, or severe.

resultsAmong 63 neonates diagnosed with DMVT, 41 exhibited moderate to severe MRI lesions. These patients were more likely to experience NDI than those with mild lesions (adjusted OR 24.3, 95% CI 4.7-180.2, P < .001). Follow-up data were available for 52 infants, of whom 40.4% developed NDI. MRI severity emerged as the strongest predictor of impaired outcomes, independent of other clinical factors such as gestational age, Apgar score, or seizures at presentation.

conclusionsNeonates with moderate or severe DMVT on MRI are at risk for NDI. The proposed MRI grading system may be a valuable classification and prognostication tool for clinicians and researchers managing DMVT in neonates.

Indexed as

Intracranial ThrombosisMagnetic Resonance ImagingMedulla OblongataNeurodevelopmental DisordersVenous ThrombosisFemaleHumansInfant, NewbornMaleRetrospective StudiesSeverity of Illness Indexbrain injurydevelopmental delayneonatologyneurology

Identifiers

PMID40783051
PMCPMC12357781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.