Evidence map›Paper›PMID 40782858›Full record

ArticleInternational journal of biological macromolecules2025

Decorated gold nanoparticles on baicalein/chitosan-modified zinc oxide nanoparticles for one-pot preparation of pyrano[2,3-d]pyrimidines and inhibiting the gastrointestinal stromal tumor progression by controlling the gene expression of the cell cycle.

Junchen Ye, Qian Shuang, Ke Wu, Yuzhi Nan, Wentao Liu, Aixiao Lu, Lingjun Kong, Jiajun Wu, Boling Zhang, Xiaolei Hou and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of biological macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Junchen YeDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Qian ShuangDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Ke WuDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Yuzhi NanDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Wentao LiuDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Aixiao LuShanxi University of Traditional Chinese Medicine, No. 121,Daxue Street, Yuci District, Jinzhong, Shanxi 030600, China.
Lingjun KongShanxi University of Traditional Chinese Medicine, No. 121,Daxue Street, Yuci District, Jinzhong, Shanxi 030600, China.
Jiajun WuShanxi University of Traditional Chinese Medicine, No. 121,Daxue Street, Yuci District, Jinzhong, Shanxi 030600, China.
Boling ZhangShanxi University of Traditional Chinese Medicine, No. 121,Daxue Street, Yuci District, Jinzhong, Shanxi 030600, China.
Xiaolei HouShanxi University of Traditional Chinese Medicine, No. 121,Daxue Street, Yuci District, Jinzhong, Shanxi 030600, China.
Shanshan LiShanxi University of Traditional Chinese Medicine, No. 121,Daxue Street, Yuci District, Jinzhong, Shanxi 030600, China.
Huifang ZhangShanxi Medical University, No. 56,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030001, China.
Lina ZhangDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Yang LiDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Ying WangDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China.
Hongbo GuoDepartment of Traditional Chinese Medicine, First Hospital of Shanxi Medical University, No. 85,Jiefang South Road, Yingze District, Taiyuan, Shanxi 030000, China. Electronic address: ghbye0317@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A composite of gold nanoparticles decorated on baicalein/chitosan-modified zinc oxide nanoparticles (ZnO@CS-baicalein/Au NPs) was synthesized and tested in a gastrointestinal stromal tumor cell line. The prepared nanocomposite was characterized using SEM and TEM, FT-IR, EDX, XRD, ICP-OES, and elemental mapping. The heterogeneous catalyst demonstrated excellent catalytic performance in synthesizing pyrano[2,3-d]pyrimidines via a three-component reaction involving malononitrile, aryl aldehydes, and barbituric acid. Additionally, ZnO@CS-baicalein/Au NPs showed good recyclability, maintaining catalytic activity after being reused eight times without significantly declining performance. When exposed to ZnO@CS-baicalein/Au NPs, the cancer cell's viability reduced, resulting in an IC

Indexed as

Cell CycleChitosanFlavanonesGastrointestinal Stromal TumorsGene Expression Regulation, NeoplasticGoldMetal NanoparticlesPyrimidinesZinc OxideAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationDisease ProgressionHumansAntineoplastic AgentsbaicaleinChitosanFlavanonesGoldPyrimidinesZinc OxideBaicaleinChitosanGastrointestinal stromal tumorGene expressionGold nanoparticlesPyrano[2,3-d]pyrimidinesZinc oxide

Identifiers

PMID40782858

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.