Evidence map›Paper›PMID 40782805›Full record

ArticleCurrent biology : CB2025

Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.

Zachary Zeidler, Marta Fernandez Gomez, Tanya A Gupta, Meelan Shari, Scott A Wilke, Laura A DeNardo

Abstract read

In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

High-fat diet exposure, internal state, and reward value influence decision making during motivational conflict.Neurobiology of stress · 2026
Article
A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility.Nature communications · 2026
Article
The Role of the Ventral Tegmental Area in Reward and Addiction: A Comprehensive Review.Neurosciences (Riyadh, Saudi Arabia) · 2026
Review
Fiber Photometry Analysis of Spontaneous Dopamine Signals: TheACS chemical neuroscience · 2025
Article

4 · The record

Corrections and comments

Update of
Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.2025

5 · Who and what money

Authors and funding

6 authors.

Zachary ZeidlerDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA.

Marta Fernandez GomezDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA.

Tanya A GuptaDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA.

Meelan ShariDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA.

Scott A WilkeDepartment of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: swilke@mednet.ucla.edu.

Laura A DeNardoDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Le Conte Ave, Los Angeles, CA 90095, USA. Electronic address: ldenardo@ucla.edu.

Funding

Prefrontal circuits underlying the maturation of learned avoidanceR01MH127214 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Laura Anne DeNardo · 2022 to 2026

$2.3M

Role of prefrontal dopamine circuits in threat avoidance learningR01MH137461 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Laura Anne DeNardo, Scott Allen Wilke · 2024 to 2026

$2.2M

Role of prefrontostriatal circuits in effort-based, cost-benefit decision makingR01MH131858 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Scott Allen Wilke · 2023 to 2026

$2.1M

Training in Neurotechnology TranslationT32NS115753 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LU, DANIEL, MARKOVIC, DEJAN · 2020 to 2024

$1.2M

Reorganization of cortical memory ensembles across timeF32MH133387 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZEIDLER, ZACHARY E · 2023 to 2025

$192k

NIMH NIH HHS F32 MH133387NIMH NIH HHS R01 MH127214NIMH NIH HHS R01 MH131858NIMH NIH HHS R01 MH137461NINDS NIH HHS T32 NS115753

6 · The paper itself

Abstract

To survive, animals must rapidly learn to avoid predictable threats. Such learning depends on detecting reliable cue-outcome relationships that efficiently drive behavioral adaptations. The medial prefrontal cortex (mPFC) integrates learned information about the environment to guide adaptive behaviors

Indexed as

Avoidance LearningDopamineDopaminergic NeuronsPrefrontal CortexVentral Tegmental AreaAnimalsCuesFearMaleMiceMice, Inbred C57BLOptogeneticsDopaminedopaminefear conditioningprefrontal cortexprelimbicthreat avoidanceventral tegmental area

Identifiers

PMID40782805

DOI10.1016/j.cub.2025.07.035

PMCPMC12338064

What OpenQuestion holds

Textmetadata

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.