ArticleNeuron2025
Direction-selective laterodorsal thalamic nucleus encodes optic flow and turning in spatial navigation.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Distinct cortical spatial representations learned along disparate visual pathways.Science advances · 2026Article
- Diversity and sensorimotor specialization of head direction cells in the mouse thalamus.Current biology : CB · 2026Article
- Anterior and posterior retrosplenial cortex form distinct visuospatial circuits in the mouse.Nature communications · 2026Article
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8 authors.
Funding
Abstract
Vision is crucial for efficient navigation, but how the brain transforms visual signals into navigational cues remains unclear. The laterodorsal thalamic nucleus (LD), with strong connections to visual and navigation circuits, is well positioned for this function, yet its role has been largely unexplored. In mice, we found that LD neurons exhibit strong direction selectivity, with a dominant directional preference for contralateral-to-ipsilateral visual motion, mirroring horizontal optic flow during contraversive turning. In freely moving animals, LD ensembles were preferentially activated during contraversive rather than ipsiversive turns in a vision-dependent manner, enabling the encoding of turning direction. Optogenetic activation or suppression of LD during learned navigational tasks selectively biased turning decisions in accordance with its directional preference. These findings suggest that by converting visual motion into egocentric turning cues, LD may serve as a critical hub linking vision to navigation and contribute to spatial cognition and memory.
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