ArticleCell reports2025
A basophil-fibroblast pro-inflammatory axis fuels type 2 skin inflammation.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- β-Sitosterol from Camellia oil integrated photothermal liposomes increasing redox-balanced anti-inflammation in macrophages.Journal of the science of food and agriculture · 2026Article
- From Barrier Disruption and Immune Dysregulation to Targeted Therapies in Atopic Dermatitis.Clinical reviews in allergy & immunology · 2026Review
- Basophils drive the resolution and promote wound healing in adult and aged mice.The Journal of experimental medicine · 2026Article
- A bibliometric analysis of trends and hotspots in Oncostatin M.Discover oncology · 2026Article
- Single-cell spatial transcriptomic analysis of human skin anatomy.Nature genetics · 2026Article
- From skin to lung: basophil-mediated spread of allergic diseases.Frontiers in immunology · 2026Review
- Basophil-specific deletion of interleukin 15 impairs memory CD8Frontiers in immunology · 2026Article
- A single-cell spatial transcriptomic census of human skin anatomy.bioRxiv : the preprint server for biology · 2025Article
- The Role of Fibroblasts in Atopic Dermatitis: Establishing Proinflammatory Microenvironments and Mediating Cellular Crosstalk.Journal of inflammation research · 2025Review
- Granulocytes and their Involvement in the Foreign Body Response to Biomaterials and Tissue Repair.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Chronic inflammatory skin diseases arise from dysregulated interactions between tissue-resident and infiltrating cells, the complexity of which hinders disease understanding and treatment. To address this, here, we present a single-cell spatiotemporal atlas of murine type 2 skin inflammation using MERFISH and scRNA-seq. Analyzing ∼430,000 cells during MC903- and oxazolone-induced dermatitis, we identify 39 cell types, including pro-inflammatory fibroblasts that resemble those in human atopic dermatitis. Spatial neighborhood analyses reveal basophils as potent activators of pro-inflammatory fibroblasts, with basophil-derived oncostatin-M (OSM) and IL-4 synergizing fibroblast-mediated feedforward basophil and immune recruitment. While fibroblast-specific deletion of the IL-4Rα receptor disrupts inflammation in vivo, the addition of pharmacologic gp130 inhibition, a core component of the OSM receptor, results in synergistic reduction of inflammation. Our study establishes a basophil-fibroblast circuitry as a critical regulator of type 2 skin inflammation, redefining basophil biology and positioning fibroblasts as dynamic immune regulators and therapeutic targets in inflammatory skin disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.