ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025
Prominent fibroblast growth factor 21 with less abundant tumor-associated macrophages in hepatic mass of the conditional mgmt-deleted mice using LysM-Cre system.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
backgroundFibroblast growth factor 21 is a molecule responsible for cell energy regulation, mainly produced from hepatocytes, while O6-methylguanine-DNA methyltransferase is a mandatory enzyme for DNA repair.
methodsBecause tumors in the livers might enhance hepatocytic FGF-21 production for supporting tumor-associated macrophages (TAM) to promote cancers, the intrahepatic tumor injection model was performed.
resultsIndeed, intrahepatic injection of MC38 cells in wild-type mice increased FGF-21 in serum and liver tissue. Murine hepatocytes excreted FGF-21 after induction by cell stresses, lipopolysaccharide, and MC38 supernatant, while human hepatocytes (HepG2) produced FGF-21 after incubation with the conditioned media of CaCO
conclusionTAM transformation in mgmt null macrophages induced more severe cell injuries than mgmt control macrophages, leading to the less abundant intratumoral TAM and increased FGF-21 to attenuate the injuries in mgmt null mice with tumors. Further studies on FGF-21 and MGMT in cancers are interesting.
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