SynthesisSleep & breathing = Schlaf & Atmung2025
Are sleep disturbances modifiable risk factors for mild cognitive impairment and dementia? A systematic review of large studies.
Synthesis in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Sleep disturbances and risk of Alzheimer's disease: a systematic review and meta-analysis of longitudinal cohort studies.Alzheimer's research & therapy · 2026Pooled it
- Longitudinal Trajectories of Cognitive Control and Theory of Mind in Amnestic and Non-Amnestic Mild Cognitive Impairment: Prospective Associations of Objective Sleep Duration.Journal of clinical medicine · 2026Article
- Mind the gap: obtaining reliable sleep estimates and the diagnostic value of sleep discrepancy in individuals with Alzheimer's disease and Lewy body disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Night-to-night rapid eye movement sleep variability: A relevant marker of early amyloid-β deposition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- Targeting the Sleep-Glymphatic-Vascular Continuum in Cerebral Small Vessel Disease: A Nutritional Perspective on Neuroprotective Potential of Tocotrienols (T3).Life (Basel, Switzerland) · 2026Review
- Assessment of Risk Factors for Cognitive Impairment Accounting for Genetic and Environmental Influences: An Italian Population-Based Twin Study.Brain sciences · 2025Article
- Sleep Trajectories in Amnestic and Non-Amnestic MCI: Longitudinal Insights from Subjective and Objective Assessments.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have shown a connection between sleep disorders, mild cognitive impairment and dementia. In this context, the present systematic review aimed to determine in large studies whether sleep disturbances are modifiable risk factors for cognitive decline. Following the application of inclusion and exclusion criteria, this systematic review selected 15 studies, with large cohort of subjects included (more than 1000 participants), who were longitudinally observed. Studies predominantly used questionnaires and interviews to collect subjective data on sleep. Eleven studies were based on subjective measurements, one was based on the International Classification of Diseases - 9th Edition diagnosis codes, and three based on objective actigraphic measurements. No study used polysomnographic assessments for the evaluation of sleep disorders.The results of this systematic review showed that extreme sleep durations (either too short or too long), daytime sleepiness, circadian sleep-wake cycle disruption, and variation in sleep patterns are factors associated with an increased risk of developing cognitive decline and dementia. Actigraphy, as an objective instrument for monitoring the sleep-wake rhythm, provided further insights into the association between sleep problems and longitudinal cognitive decline. These findings emphasize the strong connection between sleep disturbances, circadian rhythm, and the risk of developing dementia and Alzheimer's disease (AD). Sleep disorders may serve as an early indicator for cognitive decline, also considering that they may represent a modifiable risk factor for dementia. Therefore, recognition and treatment of sleep problems should be included in the prevention strategies against cognitive decline, opening up new opportunities for the prevention and treatment of cognitive impairment and AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.