ArticleVeterinary medicine and science2025
Some Predictive Indexes Are Potentially Promising Clinical Parameters in Dogs with Primary Cholangitis-Cholangiohepatitis.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular and Regenerative Effects of Platelet-Rich Plasma and Related Hemocomponents in Animal Models of Liver Injury-A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Clinical applications of blood cell ratios in veterinary hematology: From diagnosis to prognosis.Veterinary and animal science · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe invasive nature of liver biopsy and the risk of complications make patients reluctant to undergo the procedure. This situation has necessitated the search for easily accessible haematological indexes such as neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width to lymphocyte ratio (RDW/LYM) to contribute to the clinical diagnosis and prognosis evaluation processes in dogs with cholangitis-cholangiohepatitis.
objectivesThe aim of the study is to evaluate some predictive markers to contribute the clinical diagnosis in dogs with cholangitis-cholangiohepatitis. MEDHODS: Seventeen client-owned dogs with cholangitis-cholangiohepatitis were randomly allocated. Nine clinically healthy dogs (control group) confirmed with clinical examination, complete blood count (CBC) and serum profiles were used. Cholangitis-cholangiohepatitis was diagnosed in dogs with dilated bile ducts, thickened gallbladder wall up to 4 mm and increased parenchymal echogenicity. Clinical procedures including clinical examination, blood analyses and diagnostic abdominal ultrasonography were performed in all dogs. CBC indices such as NLR, mean platelet volume to platelet ratio (MPV/PLT), red cell distribution width to platelet ratio (RDW/PLT), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) and RDW/LYM were calculated using absolute CBC values.
resultsA final total of 10 dogs were enrolled in the study. NLR and RDW/LYM ratios were significantly higher (p < 00.5) in dogs with cholangitis-cholangiohepatitis compared to healthy ones.
conclusionThe results of this study suggest that the use of NLR and RDW/LYM ratio in dogs with cholangitis-cholangiohepatitis complex appears potentially promising. Larger prospective, case-control studies are needed to further evaluate these findings. Veterinary practitioners can obtain valuable diagnostic data before possible invasive liver procedures by evaluating NLR and RDW/LYM ratios, which are easily obtained from CBC parameters.
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