Evidence map›Paper›PMID 40782046›Full record

ArticleVirulence2025

The urinary microbiome distinguishes symptomatic urinary tract infection from asymptomatic older adult patients presenting to the emergency department.

Evan S Bradley, Celina Stansky, Abigail L Zeamer, Ziyuan Huang, Lindsey Cincotta, Abigail Lopes, Linda Potter, Theresa Fontes, Doyle V Ward, Vanni Bucci and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Evan S BradleyDepartment of Emergency Medicine, UMass Memorial Medical Center, Worcester, MA, USA.ORCID 0000-0001-7704-6371
Celina StanskyDepartment of Emergency Medicine, UMass Memorial Medical Center, Worcester, MA, USA.
Abigail L ZeamerProgram in Microbiome Dynamics, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-3600-4519
Ziyuan HuangProgram in Microbiome Dynamics, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-2215-2473
Lindsey CincottaDepartment of Emergency Medicine, UMass Memorial Medical Center, Worcester, MA, USA.
Abigail LopesDepartment of Emergency Medicine, UMass Memorial Medical Center, Worcester, MA, USA.
Linda PotterClinical Renal Laboratory, UMass Memorial Medical Center, Worcester, MA, USA.
Theresa FontesClinical Renal Laboratory, UMass Memorial Medical Center, Worcester, MA, USA.
Doyle V WardProgram in Microbiome Dynamics, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-4952-824X
Vanni BucciProgram in Microbiome Dynamics, UMass Chan Medical School, Worcester, MA, USA.
Beth A McCormickProgram in Microbiome Dynamics, UMass Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-5992-2673
John P HaranDepartment of Emergency Medicine, UMass Memorial Medical Center, Worcester, MA, USA.ORCID 0000-0001-7311-1121

Funding

University of Massachusetts Center for Clinical and Translational ScienceKL2TR001455 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIEFE, CATARINA I. · 2015 to 2024
$5.0M
NCATS NIH HHS KL2 TR001455
6 · The paper itself

Abstract

Older adults suffer from a high rate of asymptomatic bacteriuria (ASB), in which urinalysis may appear positive (presence of bacteria, white blood cells, and nitrates), often triggering initiation of antibiotics in acute care settings, without actual urinary tract infection (UTI) present. To investigate the urinary microbiome of older adults being tested for UTI, we enrolled a convenience sample of 250 older adult Emergency Department patients who had microscopic urinalysis ordered as part of their routine clinical care. Urinalysis results were classified as positive or negative, and patients were classified as being symptomatic or asymptomatic based on established diagnostic guidelines. We sought to determine if features of the urinary microbiome differed between positive and negative urinalysis (UAs) and symptomatic and asymptomatic patients with positive UAs. The same urine sample used for clinical testing was sequenced and analyzed for bacterial taxa, metabolic pathways, and known bacterial virulence factors. After exclusion of anatomical abnormalities and filtering for sequencing quality, 152 samples were analyzed (5 negative UAs, 147 positive UAs, among which 68 were asymptomatic, and 79 symptomatic). Positive UA samples showed significantly lower alpha diversity (2.29 versus 0.086,

Indexed as

Asymptomatic InfectionsMicrobiotaUrinary Tract InfectionsUrineAgedAged, 80 and overBacteriaBacteriuriaEmergency Service, HospitalFemaleHumansMaleMiddle AgedUrinalysisasymptomatic bacteriuriaemergency departmentmachine learningmetagenomic analysisolder adultsUrinary tract infection

Identifiers

PMID40782046
PMCPMC12351761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.