Evidence map›Paper›PMID 40782044›Full record

ArticleHuman brain mapping2025

Estimating Brain Similarity Networks With Diffusion MRI.

Amir Sadikov, Hannah L Choi, Lanya T Cai, Pratik Mukherjee

Abstract read
In one paragraph

Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Amir SadikovRadiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Hannah L ChoiRadiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Lanya T CaiRadiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Pratik MukherjeeRadiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0001-7473-7409

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
The Human Connectome Project (HCP)U01MH093765 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2010 to 2014
$12.1M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Neural Mechanisms of Sensory OverResponsivityR01MH116950 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARCO, ELYSA JILL, MUKHERJEE, PRATIK · 2019 to 2023
$2.7M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
Computeserver Structural &Functional Image AnalysisS10RR019307 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2004 to 2004
$496k
McDonnell Center for Systems Neuroscience at Washington UniversityNCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIBIB NIH HHS P41 EB015896NIH HHS 1S10RR019307NIH HHS 1S10RR023401NIH HHS 5R01MH116950NIH HHS P41EB015896NIH HHS S10RR023043NIMH NIH HHS R01 MH116950NIMH NIH HHS U01 MH093765NIMH NIH HHS U54 MH091657U.S. Department of Defense W81XWH-14-2-0176
6 · The paper itself

Abstract

Structural similarity has emerged as a promising tool in mapping the network organization of an individual, living human brain. Here, we propose diffusion similarity networks (DSNs), which employ rotationally invariant spherical harmonic features derived from diffusion magnetic resonance imaging (dMRI), to map gray matter structural organization. Compared to prior approaches, DSNs showed clearer laminar, cytoarchitectural, and micro-architectural organization; greater sensitivity to age, cognition, and sex; higher heritability in a large dataset of healthy young adults; and straightforward extension to non-cortical regions. We show DSNs are correlated with functional, structural, and gene expression connectomes, and their gradients align with the sensory-fugal and sensorimotor-association axes of the cerebral cortex, including neuronal oscillatory dynamics, metabolism, immunity, and dopaminergic and glutaminergic receptor densities. DSNs can be easily integrated into conventional dMRI analysis, adding information complementary to structural white matter connectivity, and could prove useful in investigating a wide array of neurological and psychiatric conditions.

Indexed as

BrainCerebral CortexConnectomeDiffusion Magnetic Resonance ImagingGray MatterNerve NetAdultFemaleHumansImage Processing, Computer-AssistedMaleYoung Adultbrain networksconnectomediffusion MRIgray matter microstructuremorphometric similaritystructural covariance

Identifiers

PMID40782044
PMCPMC12335008

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.