Evidence map›Paper›PMID 40782020›Full record

Observational studyPerfusion2026

Prone positioning and bleeding risk during extracorporeal membrane oxygenation in severe ARDS patients.

Alessio Caccioppola, Francesco Padovano, Vittorio Scaravilli, Fabiana Madotto, Cristina Dulama, Alfredo Lissoni, Mauro Panigada, Giacomo Grasselli

Abstract readObservational Study
In one paragraph

Observational study in Perfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessio CaccioppolaDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0003-1936-3111
Francesco PadovanoDepartment of Surgical and Medical Science, Anesthesia and Intensive Care Unit, Policlinico Riuniti di Foggia, University of Foggia, Foggia, Italy.
Vittorio ScaravilliDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0003-0877-7626
Fabiana MadottoDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Cristina DulamaDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Alfredo LissoniDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Mauro PanigadaDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Giacomo GrasselliDepartment of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PurposeTo assess whether prone positioning (PP) increases bleeding risk compared to supine positioning in ARDS patients undergoing veno venous Extracorporeal Membrane Oxygenation (VV ECMO).Materials and MethodsA single-center retrospective observational study was conducted between January 2012 and March 2023. Data were systematically collected from an institutional ECMO registry, including baseline characteristics, daily variables, bleeding events, and outcomes. We compared the relative risk (RR) and incidence rate ratio (IRR) of bleeding between 'Prone' and 'Supine' patients. Bleeding-free days were analyzed using Kaplan-Meier curves and the Log-Rank test.ResultsWe included 136 consecutive severe ARDS patients undergoing VV ECMO (65% male, age 52 ± 11, 53% bacterial pneumonia), with 85 (62%) and 51 (38%) in the 'Prone' and 'Supine' group respectively. Bleeding occurred in 79 (58%) patients, with 43 of these being major bleeding events, including 14 intracranial hemorrhages. Fifty-two (61%) 'Prone' patients versus 27 (53%) 'Supine' patients had bleeding (RR 1.11 (95% CI: 0.81-1.52),

Indexed as

Extracorporeal Membrane OxygenationHemorrhageRespiratory Distress SyndromeAdultFemaleHumansMaleMiddle AgedProne PositionRetrospective StudiesRisk FactorsARDSbleedingextracorporeal membrane oxygenationprone positionVV ECMO

Identifiers

PMID40782020
PMCPMC13144657

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