Evidence map›Paper›PMID 40781971›Full record

ReviewPhytotherapy research : PTR2025

Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis.

Yipeng Lin, Janney Z Wang, Yihe Niu, Ling Zhu, Rujee K Duke, Colin C Duke, Michael Murray, Fanfan Zhou

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Phytotherapy research : PTR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Wound-Healing Efficacy ofFood science & nutrition · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yipeng LinMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Janney Z WangMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Yihe NiuMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Ling ZhuMacular Research Group, Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Rujee K DukeMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Colin C DukeMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Michael MurrayMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Fanfan ZhouMolecular Drug Development Group, Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-1982-1541

Funding

Faculty of Medicine and Health, University of Sydney (SOMS honors scholarship)
6 · The paper itself

Abstract

Propolis is a plant-derived substance collected by honeybees that has a range of potential therapeutic applications. Propolis consists of resins, waxes, and fatty acids, as well as essential oils and other organic compounds. The pharmacologically active components of propolis include phenols and flavonoids, among others. Flavonoids that are found in propolis include chrysin, quercetin, galangin, kaempferol, and apigenin. Angiogenesis is the growth of new blood vessels from endothelial cell precursors. Angiogenesis is important in normal physiology and development. Pathological angiogenesis is widely implicated in human diseases, such as retinal diseases, cancers, and inflammatory diseases; currently, many of these conditions lack effective treatments. The process of angiogenesis is modulated by pro-angiogenic factors, in particular, Vascular Endothelial Growth Factor (VEGF). Flavonoids, including several that are present in propolis, have been found to inhibit angiogenesis by attenuating VEGF signaling. Although promising, such findings are primarily based on preclinical studies, and few clinical studies have evaluated the efficacy and toxicity of flavonoids in vivo. This review outlines the therapeutic potential of essential flavonoids from propolis that may have value as anti-angiogenic agents by modulating VEGF signaling. Overall, the findings suggest that flavonoids that are present in propolis are potential agents for the treatment of human diseases in which pathological angiogenesis is activated.

Indexed as

Angiogenesis InhibitorsFlavonoidsNeovascularization, PathologicPropolisSignal TransductionVascular Endothelial Growth Factor AAngiogenesisAnimalsHumansAngiogenesis InhibitorschrysinFlavonoidsPropolisVascular Endothelial Growth Factor Aangiogenesisflavonoidsinflammationintraocular neovascular syndromespropolissolid tumourVEGF

Identifiers

PMID40781971
PMCPMC12423498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.