ReviewJournal of cosmetic dermatology2025
Enzymatic Management of Facial Overfilled Syndrome: A Case Series and Narrative Review.
Review in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Ultrasound imaging in aesthetic medicine: safety and precision in injectable procedures.Journal of ultrasound · 2026Review
- A Case Series on a Layered Biomaterial Strategy for Midface Rejuvenation: Combining Collagen Stimulators and Hyaluronic Acid.Journal of cosmetic dermatology · 2026Article
- The Fear of Overfilling (FOF): A Clinically Significant Response to Digital Aesthetics and the Dermatologist's Imperative to Preserve Facial Identity.Journal of cosmetic dermatology · 2026Article
- Facial Overfilled Syndrome: A Narrative Clinical Review.Clinical, cosmetic and investigational dermatology · 2026Review
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
- Enzymatic Management of Facial Overfilled Syndrome: A Case Series and Narrative Review.Journal of cosmetic dermatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFacial overfilled syndrome (FOS) is an increasingly recognized complication of injectable aesthetic procedures, characterized by undesirable facial volume and contour irregularities. While hyaluronidase is well-established for managing hyaluronic acid (HA) filler complications, treating FOS caused by non-HA fillers, such as fat and silicone, remains challenging.
objectiveThis study aims to present the results of a novel enzymatic therapy combining hyaluronidase, collagenase, and lipase for treating FOS in five patients with complications from HA, fat, and silicone fillers. Additionally, we conducted a narrative literature review of studies published between 2015 and 2024, focusing on FOS and its management.
methodsWe performed a narrative literature review using PubMed and Google Scholar databases, identifying six key papers that specifically address FOS. Following this, we present a case series of five patients treated with a combination of 1.5 mL collagenase, 1.5 mL hyaluronidase (HASA), and 1.5 mL lipase (total volume: 4.5 mL). Enzymatic therapy was administered via cannula under ultrasound guidance, and outcomes were assessed through clinical evaluation and patient-reported satisfaction.
resultsAll five patients significantly improved facial volume and contour restoration after a single treatment session. The enzymatic combination effectively addressed complications from HA, fat, and silicone fillers, with no significant adverse events reported. Patient satisfaction improved significantly, highlighting the psychological benefits of the treatment.
conclusionCombining hyaluronidase, collagenase, and lipase represents a safe and effective approach for managing FOS caused by various filler types. Our study, supported by a narrative review of six key papers on FOS, underscores the importance of tailored enzymatic therapies in aesthetic medicine and calls for further research to optimize treatment protocols and expand the evidence base.
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