Evidence map›Paper›PMID 40781904›Full record

Trial reportDrug testing and analysis2025

mRNA Biomarkers in Dried Blood Spots May Improve Detection of Autologous Blood Micro-Transfusions Using an Individualized Approach.

Andreas Breenfeldt Andersen, Jessica Almeida Oliveira, Francesco Loria, Jacob Bejder, Olivier Salamin, Tiia Kuuranne, Nikolai B Nordsborg, Nicolas Leuenberger

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug testing and analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andreas Breenfeldt AndersenDepartment of Public Health, Research Unit for Exercise Biology, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-3361-3009
Jessica Almeida OliveiraSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne & Geneva, Lausanne University Hospital & University of Lausanne, Lausanne, Switzerland.
Francesco LoriaSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne & Geneva, Lausanne University Hospital & University of Lausanne, Lausanne, Switzerland.
Jacob BejderDepartment of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-9698-9188
Olivier SalaminSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne & Geneva, Lausanne University Hospital & University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-0388-1352
Tiia KuuranneSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne & Geneva, Lausanne University Hospital & University of Lausanne, Lausanne, Switzerland.
Nikolai B NordsborgDepartment of Nutrition, Exercise and Sports (NEXS), University of Copenhagen, Copenhagen, Denmark.
Nicolas LeuenbergerSwiss Laboratory for Doping Analyses, University Center of Legal Medicine, Lausanne & Geneva, Lausanne University Hospital & University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0001-7106-6304

Funding

World Anti-Doping Agency DBS20ABP03NN
6 · The paper itself

Abstract

Autologous blood transfusions (ABTs) are prohibited by the World Anti-Doping Agency (WADA), yet detecting autologous blood micro-transfusions (ABMTs) remains a challenge. Due to smaller transfused volumes, ABMTs cause attenuated biomarker changes, limiting detection sensitivity within the Athlete Biological Passport (ABP). This study assessed whether mRNA expression of 5-aminolevulinic acid synthase (ALAS2) and carbonic anhydrase 1 (CA1), measured from dried blood spots (DBS), could serve as sensitive biomarkers of ABMT. In a randomized, placebo-controlled design, 47 trained individuals (24 ♀; mean VO

Indexed as

5-Aminolevulinate SynthetaseBlood Transfusion, AutologousCarbonic AnhydrasesDried Blood Spot TestingRNA, MessengerSubstance Abuse DetectionAdultBiomarkersDoping in SportsFemaleHumansMaleYoung Adult5-Aminolevulinate SynthetaseALAS2 protein, humanBiomarkersCarbonic AnhydrasesRNA, Messenger

Identifiers

PMID40781904
PMCPMC12580161

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.