Trial reportPhysiological reports2025
The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness.
Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The impact of topical capsaicin application on the muscle metaboreflex and microvascular responsiveness.Physiological reports · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Topical capsaicin reduces metaboreflex responses during post-exercise circulatory arrest (PECA) in males, but its effects in females and on microvascular responsiveness in either sex remain unclear. This study hypothesized that capsaicin would reduce blood pressure during PECA in males but not females, and enhance microvascular responsiveness in both sexes. Healthy males (n = 9) and females (n = 11) were randomly assigned to one of three conditions: capsaicin applied to the exercising arm, capsaicin applied to the non-exercising arm, or no capsaicin (control). Blood pressure was measured via the brachial artery during a handgrip exercise at 30% maximal voluntary contraction, followed by PECA using a rapid inflation cuff. Microvascular responsiveness was assessed with near-infrared spectroscopy (NIRS) during a post-occlusive reactive hyperemia test, conducted before and twice after capsaicin application. Capsaicin did not significantly alter blood pressure during PECA (p > 0.05), but a significant interaction was observed for microvascular responsiveness (p = 0.01). Although topical capsaicin did not attenuate metaboreflex-induced blood pressure changes, it enhanced microvascular responsiveness in the exercising arm compared to the systemic control. These findings suggest localized vascular benefits of capsaicin, but no clear impact on the metaboreflex. Further research is needed to clarify sex-specific responses to topical capsaicin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.