Evidence map›Paper›PMID 40781866›Full record

ArticleJournal of clinical ultrasound : JCU2026

Ultrasound-Based Z Score and Pulmonary Valve/Aortic Valve Diameter Ratio Improving the Predictive Value of Fetal Aortic Stenosis.

M Heqing Guo, M Hua Yuan, M Bowen Zhao, B Qiqi Hua, B Linhua Wang

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Article in Journal of clinical ultrasound : JCU, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

M Heqing GuoDepartment of Ultrasound, Shaoxing Maternity and Child Health Care Hospital, Maternity and Child Health Care Affiliated Hospital, Shaoxing University, Shaoxing, China.ORCID https://orcid.org/0000-0001-7474-6604
M Hua YuanDepartment of Ultrasound, Shaoxing Maternity and Child Health Care Hospital, Maternity and Child Health Care Affiliated Hospital, Shaoxing University, Shaoxing, China.ORCID https://orcid.org/0000-0001-8062-0952
M Bowen ZhaoDepartment of Diagnostic Ultrasound & Echocardiography, Sir Run Run Shaw Hospital Affiliated to Zhejiang University College of Medicine, Hangzhou, China.
B Qiqi HuaDepartment of Ultrasound, Shaoxing Maternity and Child Health Care Hospital, Maternity and Child Health Care Affiliated Hospital, Shaoxing University, Shaoxing, China.
B Linhua WangDepartment of Ultrasound, Shaoxing Maternity and Child Health Care Hospital, Maternity and Child Health Care Affiliated Hospital, Shaoxing University, Shaoxing, China.

Funding

Science and Technology Program of Shaoxing, Zhejiang province China 2023A14033Science and Technology Program of Shaoxing, Zhejiang province China 2024A14026Zhejiang Province Medical and Healthy Project of China 2022KY410Zhejiang Province Medical and Healthy Project of China 2024KY1734
6 · The paper itself

Abstract

objectiveThis study aims to investigate the predictive value of the ultrasound-based Z score for the aortic valve (AV) diameter, pulmonary valve (PV) Z score, and the PV/AV ratio in diagnosing aortic stenosis (AS) in fetuses.

methodsA prospective study of 24 singleton fetuses with suspected AS who underwent two or more fetal echocardiograms was enrolled. Based on the pregnancy outcomes, the prenatal cases were divided into two groups: the AS group and the false-positive group. Electronic spatiotemporal image correlation (eSTIC) technology was used to measure AV and PV of all fetuses, and the AV and PV Z scores, along with the PV/AV ratio, were calculated, compared, and analyzed.

resultsIn the AS group, significant differences were found between the first and second echocardiograms regarding the AV Z score, PV Z score, and PV/AV ratio. In the false-positive group, only the PV Z score and PV/AV ratio showed significant differences. In the first echocardiogram, the AV Z score and PV/AV ratio significantly differed between the AS and false-positive groups. In the second echocardiogram, only the AV Z score showed differences. An AV Z score < -2.46 showed high sensitivity (89.5%) and specificity (100%) for AS diagnosis. When combined with a PV/AV ratio > 1.64, the predictive value increased.

conclusionFetal echocardiography with an AV Z score <-2.46 and a PV/AV ratio > 1.64 provides a higher predictive value for diagnosing AS in fetuses.

Indexed as

Aortic ValveAortic Valve StenosisEchocardiographyPulmonary ValveUltrasonography, PrenatalAdultFemaleHumansPredictive Value of TestsPregnancyProspective StudiesSensitivity and Specificityaortic stenosisfetal echocardiographyPV/AV ratioZ score

Identifiers

PMID40781866
PMCPMC12766868

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