Evidence map›Paper›PMID 40781842›Full record

ArticleCancer2025

Assessing the impact of multidisciplinary team gynecological oncology care in Botswana: A potential model for low- and middle-income countries.

Emily MacDuffie, Camille McCallister, Jessica George, Barati Monare, Rebecca Ketlametswe, Gaobakwe Ramontshonyana, Annah Mmari, Maitumelo Pharithi, Lydiah Mntande, Peter Vuylsteke and 7 more

Abstract read
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emily MacDuffieDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Camille McCallisterDivision of Gynecologic Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0009-0003-0959-6197
Jessica GeorgeDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-0319-4272
Barati MonarePrincess Marina Hospital, Gaborone, Botswana.
Rebecca KetlametswePrincess Marina Hospital, Gaborone, Botswana.
Gaobakwe RamontshonyanaPrincess Marina Hospital, Gaborone, Botswana.
Annah MmariPrincess Marina Hospital, Gaborone, Botswana.
Maitumelo PharithiPrincess Marina Hospital, Gaborone, Botswana.
Lydiah MntandePrincess Marina Hospital, Gaborone, Botswana.
Peter VuylstekePrincess Marina Hospital, Gaborone, Botswana.
Lisa Bazzett-MatabelePrincess Marina Hospital, Gaborone, Botswana.
Caroline KernellUT Southwestern Medical School, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-3624-9882
Kgosi HughesUniversity of Oklahoma College of Medicine, Oklahoma City, Oklahoma, USA.
Megan KassickDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Memory Bvochora-NsingoGaborone Private Hospital, Gaborone, Botswana.
Katharine A RendleDepartment of Family Medicine and Community Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Surbhi GroverDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Shared Resources CoreU54CA190158 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2014 to 2023
$4.2M
Prognostic value of quantitative HPV viral load in determining cervical cancer treatment response and recurrenceK08CA230170 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GROVER, SURBHI · 2019 to 2023
$1.4M
Center for AIDS Research 5-P30-AI-045008-17Department of Radiation Oncology at the University of PennsylvaniaMentored Patient-Oriented Career Research Development Award 1-K08CA230170-01A1NCI NIH HHS K08 CA230170NCI NIH HHS U54 CA190158Sub-Saharan African Collaborative HIV and Cancer Consortia-U54 1U54CA190158-01
6 · The paper itself

Abstract

backgroundIn Botswana, a multidisciplinary team (MDT) clinic was established in 2015 to streamline care for all patients with gynecological malignancies including cervical cancer, Botswana's leading cause of cancer mortality.

methodsPatients presenting at the MDT clinic in Gaborone, Botswana, were prospectively enrolled. Temporal trends in stage and treatment distributions were assessed using the Cochran-Armitage χ

resultsBetween 2015 and 2023, 2345 patients were enrolled. Mean age was 52.0 years (SD 13.1 years) and 62.9% (n = 1474) were living with HIV. Annual volume increased 4-fold by 2023. Most patients had cervical cancer (74.3%), followed by vulvar (11.9%), endometrial (8.8%), ovarian (3.6%), and vaginal (1.3%) cancers. Stage distribution was: Stage I 19.2%, Stage II 23.9%, Stage III 31.3%, and Stage IV 9.4%. Trends toward increased diagnosis of Stage I disease (p < .0018) and decreased diagnosis of Stage II disease (p = .002) were observed in cervical cancer patients over the years of MDT consultation. Two-year overall survival for patients with cervical cancer treated between 2015 and 2019 was 67.1% and increased to 75.2% between 2020 and 2024 (p = .002), potentially driven by increased survival of those with Stage II disease (75.7% vs. 84.8%, p = .025). This coincided with an increase in patients with cervical cancer receiving primary surgery (p < .001) and a decrease in those receiving radiotherapy with concurrent chemotherapy (p < .001) and radiotherapy alone (p < .001). DISCUSSION: Gynecological cancer outcomes after MDT clinic establishment significantly improved over time. Although ongoing efforts to optimize care are still needed, the success of the MDT clinic in Botswana can serve as a model for coordinated multidisciplinary care in other low-resource settings.

Indexed as

Genital Neoplasms, FemaleMedical OncologyPatient Care TeamAdultAgedBotswanaDeveloping CountriesFemaleHumansMiddle AgedNeoplasm StagingProspective StudiesUterine Cervical Neoplasmscervical cancergynecological cancerlow‐middle income countrymultidisciplinary team

Identifiers

PMID40781842
PMCPMC12334905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.