SynthesisHeadache2025
Cerebrospinal fluid and serum biomarkers in idiopathic intracranial hypertension: A systematic review.
Synthesis in Headache, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebrospinal fluid and serum biomarkers in idiopathic intracranial hypertension: A systematic review.Headache · 2025Pooled it
- Human biomarker navigator.iMeta · 2026Review
- Craniocervical Junction Morphology and Cerebrospinal Fluid Spaces at the Foramen Magnum in Idiopathic Intracranial Hypertension: Implications for Pathophysiology.Journal of clinical medicine · 2026Article
- Idiopathic Intracranial Hypertension in a Child with Marfan Syndrome: Clinical, Neuroimaging, and Biomarker Findings from a Case Report.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to systematically review the literature on soluble biomarkers in adults with idiopathic intracranial hypertension (IIH).
backgroundIdiopathic intracranial hypertension is a multifactorial disorder marked by elevated intracranial pressure without a clear cause. Although it primarily affects overweight women of reproductive age, its pathogenesis remains incompletely understood. Symptoms include headache and visual disturbances due to papilledema. Increasing attention has focused on soluble biomarkers in serum and to understand disease mechanisms and aid diagnosis and management.
methodsThis systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and registered in PROSPERO (CRD420250630653). The systematic literature search was conducted across PubMed, Web of Science, and Scopus for studies published in English between January 1995 and December 2024. Articles investigating cerebrospinal fluid (CSF) and/or blood biomarkers in adult patients with IIH were included. Multiple reviewers independently conducted screening, data extraction, and quality assessment. The risk of bias was evaluated using the ROBINS-I tool.
resultsA total of 38 studies on serum/plasma, urine, and CSF biomarkers met the inclusion criteria. The identified biomarkers were categorized into five main groups: (1) metabolic/endocrine, (2) systemic and neurogenic inflammation, (3) neurodegeneration, (4) neural antibodies and CSF dynamics, and (5) miscellaneous. Consistently elevated leptin levels were reported across studies, alongside evidence of cortisol dysregulation, altered androgen profiles, and insulin resistance. Inflammatory markers were frequently elevated, indicating a state of low-grade systemic inflammation; however, findings regarding specific inflammatory markers were variable and lacked consistency. Two studies evaluated calcitonin gene-related peptide (CGRP) in plasma, finding elevated levels in IIH, especially in those with migraine-like headache. Neuronal markers like neurofilament light chain (NfL) were increased and correlated with disease severity. Emerging candidates included microRNAs, metabolites identified through metabolomic approaches, and novel proteins discovered via proteomic analyses.
conclusionsIIH appears to involve interplay of inflammatory, metabolic, and neurodegenerative processes. Although androgen dysregulation, leptin, and NfL show the most consistent association, substantial heterogeneity in study methods and populations limits generalizability. CGRP may emerge as a promising biomarker reflecting the predominant clinical symptom-headache-potentially guiding future therapeutic strategies.
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