Evidence map›Paper›PMID 40781730›Full record

ArticleMedical physics2025

Framework to calculate

Shahin Ghaseminejad, Danny De Sarno, Glenn Bauman, Ting-Yim Lee

Abstract read
In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Monte Carlo simulations ofMedical physics · 2026
    Article
  2. Review
  3. Article
  4. Framework to calculateMedical physics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shahin GhaseminejadDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Danny De SarnoDepartment of Medical Biophysics, Western University, London, Ontario, Canada.
Glenn BaumanDepartment of Radiation Oncology, London Health Sciences Centre, London, Ontario, Canada.
Ting-Yim LeeDepartment of Medical Biophysics, Western University, London, Ontario, Canada.

Funding

Canada Foundation for InnovationCIHROntario Institute of Cancer ResearchOntario Research Fund
6 · The paper itself

Abstract

backgroundIn the treatment of metastatic castration-resistant prostate cancer (mCRPC), the standard radionuclide PURPOSE: This Study aims to develop a comprehensive pipeline based on Monte Carlo (MC) simulations to compare the therapeutic efficacy of

methodsA 2 µm resolution cell model was constructed with a 20 µm cell, an 8 µm nucleus diameter, and a 26 µm center-to-center distance. This configuration resulted in a cellular fraction of 0.24 mL/g, in agreement with that estimated from six prostate cancer patients using CT Perfusion. The prostate time-integrated activity (TIA) in the model was estimated from a patient based on a dynamic 300 MBq

resultsThe cellular absorbed dose was higher than the macro-scale dose based on SPECT-derived TIA, by 31.3%, 15.7%, and 39.8% for

conclusionsDPKs and BECKs of

Indexed as

ActiniumLutetiumProstatic Neoplasms, Castration-ResistantRadiation DosageRadioisotopesHumansMaleMonte Carlo MethodNeoplasm MetastasisRadiotherapy DosageActiniumActinium-225LutetiumLutetium-177Radioisotopes161Tb177Lu225Acbiologic effect cell kernelcellular fractionDNA breaksdose point kerneldosimetryMonte Carlo simulationrelative biological effectivenesstargeted radionuclide therapy

Identifiers

PMID40781730
PMCPMC12334816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.