ArticleJournal of ovarian research2025
Global profiling of protein lactylome in porcine granulosa cells.
Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Global profiling of the protein lactylome in porcine liver.BMC genomics · 2026Article
- Research progress on protein lactylation in female reproductive disease: molecular mechanisms, functions, and therapeutic implications.Frontiers in pharmacology · 2026Review
- Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in piglets.Communications biology · 2025Article
- Lactylation in post-stroke fatigue: linking metabolic dysregulation to neuroinflammation.Frontiers in neuroscience · 2025Review
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Authors and funding
11 authors.
Funding
Abstract
backgroundIn mammals, granulosa cells (GCs) use glycolysis as the main energy source for oocyte development. Lactate, the end product of glycolysis, covalently binds lysine. Residues in proteins through an enzymatic or non-enzymatic method known as lysine lactylation (Kla), which plays a role in epigenetics. Histone lactylation positively regulates reproduction. However, the roles of non-histone proteins in reproduction remain unclear. Based on the abundance of lactate in GCs, we first profiled the global lactylome in porcine GCs.
resultsWe identified 24,038 lactylation sites in 6,255 proteins, the largest number to date, indicating the richness of lactylation in GCs. Histones from porcine, humans, and mice are conserved at most sites, with some sites being specific to porcine such as H4K79. Kla proteins were significantly enriched in energy metabolism-related pathways, with all the enzymes involved in the tricarboxylic acid cycle and glycolysis undergoing lactylation. We also preliminarily illustrated the mechanism by which decreased protein lactylation induces ferroptosis.
conclusionsOur study provides a comprehensive understanding of lactylation in mammalian GCs and lays the foundation for subsequent studies on the lactylation-mediated regulation of female reproductive function.
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