ArticleBMC sports science, medicine & rehabilitation2025
Impact of aerobic exercise on chronic inflammation in older adults: a systematic review and meta-analysis.
Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Myokine Signaling in Sarcopenia-Associated Chronic Musculoskeletal Pain: A Systematic Review of Inflammatory Mechanisms.International journal of molecular sciences · 2026Pooled it
- Comparative efficacy of different modes of exercise on inflammatory markers in patients with chronic kidney disease: a systematic review with pairwise and network meta-analyses.Scientific reports · 2026Pooled it
- Comparative efficacy of exercise modes on cardiometabolic health in women with polycystic ovary syndrome: a systematic review with pairwise and network meta-analyses.BMC women's health · 2026Pooled it
- The impact of exercise on inflammatory biomarkers: an umbrella review of systematic reviews and meta-analyses.Frontiers in immunology · 2026Pooled it
- Within-Day Timing of Concurrent Training Affects Inflammation and Body Composition in Young Adults With Obesity.Obesity (Silver Spring, Md.) · 2026Trial
- Exercise-induced neuropeptidergic and neurochemical neuroadaptation in stress regulation and emotional disorders.Acta neurologica Belgica · 2026Review
- Patient stratification in exercise oncology: matching exercise modalities to immune phenotypes to optimize immunotherapy response.Translational oncology · 2026Review
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- Frequency-dependent adaptations in energy expenditure, strength, mood, and inflammation following 16 to 32 weeks of combined aerobic and resistance training in older women.European journal of applied physiology · 2026Article
- Exercise-associated changes in leptin and irisin relate to cognitive function in older adults stratified by cognitive impairment.Scientific reports · 2026Article
- Inflammaging and Sarcopenia as Interconnected Hallmarks of Aging: Integrative Roles of Bioactive Compounds and Lifestyle Interventions.Nutrients · 2026Review
- Exercise and smoking: health rivals revealing shared protective mechanisms in Parkinson's?NPJ Parkinson's disease · 2026Review
- Effect of Moderate Aerobic Exercise on Body Composition, Biochemical Parameters and Oxidative Damage in Older Women Without and With Metabolic Syndrome.Journal of functional morphology and kinesiology · 2026Article
- Exercise, Cellular Senescence, and Cancer: Novel Perspectives on Functional Aging Through Block Strength Training in Older Adults-A Narrative Review.Biomedicines · 2026Review
- Cardiovascular disease, 24-h movement behaviors and all-cause mortality: a compositional mediation analysis based on a prospective cohort.Journal of exercise science and fitness · 2026Article
- Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer.Frontiers in immunology · 2026Review
- Effects and mechanisms of different exercise modalities on inflammation in older adults, particularly with sarcopenia: a narrative review.Frontiers in medicine · 2026Review
- Impact of moderate treadmill training on cytokine levels in rats: influence of age and sex.Frontiers in aging · 2026Article
- The effects of aerobic exercise on sleep quality in older adults with sleep problems: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychology · 2026Review
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to conduct a systematic review and meta-analysis to investigate the effect of aerobic exercise training on inflammatory markers in older adults. The current literature was searched using PubMed, Scopus, Web of Science, and Google Scholar to identify controlled clinical trials in English. Ten articles met the inclusion criteria. The mean difference (MD) with 95% confidence intervals (CIs) and the overall effect size was calculated for all comparisons. The PEDro scale was used to evaluate the quality of articles. The findings indicated that aerobic exercise training led to an improvement in inflammatory markers in older adults: IL-6 (mean difference = 0.939, Z = 2.857, P = 0.004), CRP (mean difference = 0.853, Z = 3.060, P = 0.002), TNF-α (mean difference = 0.705, Z = 3.094, P = 0.002), IL-10 (mean difference = 1.511, Z = 2.036, P = 0.042). This review demonstrates that aerobic exercise training significantly improves inflammatory markers in older adults, reducing CRP, TNF-α, and IL-6, while increasing IL-10, with particular benefits for populations at risk for chronic inflammatory diseases. According to the results of this review, an effective aerobic exercise program should include moderate to high intensity (60-80% HRmax or HRR), sessions lasting 30 to 60 min, and a frequency of 2 to 3 times per week.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.