ArticleBMC public health2025
Global, regional, and National burden of urticaria (1990-2021), its potential risk factors, and projections to 2046.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.Allergy · 2026Guideline
- Why physicians underuse patient-reported outcomes in atopic dermatitis and chronic urticaria - Insights from the UCARE/ADCARE PROMUSE study.The World Allergy Organization journal · 2026Article
- Nanomaterials in Targeted Immunotherapy for Chronic Spontaneous Urticaria: Focusing on Immune Cell Modulation and Precision Treatment.International journal of nanomedicine · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
backgroundUrticaria is a common inflammatory skin disorder that causes distressing symptoms, significantly impacting the quality of life of patients and imposing a substantial burden on society.
objectiveThis study aimed to enhance policymakers' awareness of the burden of urticaria and encourage the rational allocation of health resources.
methodsWe utilized data from the Global Burden of Disease (GBD) Results (2021) to obtain prevalence, incidence, and disability-adjusted life years (DALYs) for urticaria from 1990 to 2021, categorized by age, gender, and region. A Bayesian age-period-cohort (BAPC) model with integrated nested Laplace approximation (INLA) was employed to project global incidence trends through 2046. Correlations between air pollution levels, dietary intake, and urticaria incidence were analyzed using Spearman's rank-order correlation.
resultsFrom 1990 to 2021, the global burden of urticaria increased gradually, reaching 66.48 million cases in 2021. Females and younger age groups had higher burdens. Projections indicate a continued rise through 2046. Moderate positive correlations were found between urticaria incidence and ozone (rho = 0.349, p < 0.0001) and particulate matter (PM) (rho = 0.389, p < 0.0001), with a weak correlation to NO₂ (rho = 0.249, p = 0.0003). Dietary intake of calcium, milk, processed meats, sugar-sweetened beverages (SSBs), trans fats, and vegetables was positively associated with urticaria, while legumes, nuts, omega-3 fatty acids, and whole grains were negatively correlated.
conclusionUrticaria poses a significant global health concern, with rising incidence projected by 2046. The findings highlight correlations between air pollution and dietary factors, suggesting potential protective effects of certain foods.
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