ArticleBMC psychiatry2025
Prevalence and correlates of suicide attempts in working-age, first-episode, drug-naïve major depressive disorder patients.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Suicide attempts are a critical concern among first-episode, drug-naïve (FEDN) patients with major depressive disorder (MDD). This cross-sectional study investigated the prevalence and correlates of suicide attempts in 1,701 working-age Chinese adults (18-59 years) with FEDN MDD. Sociodemographic data, clinical assessments, and biochemical data were obtained. Overall, 20.2% of participants reported lifetime suicide attempts. Multiple logistic regression identified four independent correlates: Hamilton Anxiety Scale (HAMA), clinical global impression of severity scale (CGI-s), systolic blood pressure, and thyroid peroxidase antibody levels. Additional analysis revealed significant pro-atherogenic lipid profile alterations in suicide attempters. Receiver operating characteristic curve analysis highlighted the high discriminative ability of HAMA and CGI-s for identifying suicide attempts. These findings underscore the importance of integrating psychological, cardiovascular, and metabolic markers in routine suicide risk evaluation for working-age FEDN MDD patients. Incorporating anxiety, blood pressure, lipid metabolism, and thyroid autoantibody assessment may enhance early detection and inform targeted interventions.
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