Evidence map›Paper›PMID 40781626›Full record

ReviewOrphanet journal of rare diseases2025

Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational research.

Biagio Palmisano, Camryn Berry, Alison Boyce, Julia F Charles, Michael T Collins, Alessandro Corsi, Fernando A Fierro, Anne-Marie Heegaard, Hanne van der Heijden, Charles S Hoffman and 8 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Orphanet journal of rare diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Biagio PalmisanoDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, 00161, Italy.
Camryn BerryDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Alison BoyceMetabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Julia F CharlesDepartments of Orthopaedic Surgery and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Michael T CollinsMetabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Alessandro CorsiDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, 00161, Italy.
Fernando A FierroInstitute for Regenerative Cures, University of California Davis, Sacramento, CA, 95817, USA.
Anne-Marie HeegaardDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, 2100, Denmark.
Hanne van der HeijdenDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Charles S HoffmanBiology Department, Boston College, 140 Commonwealth Ave, Chestnut Hill, MA, 02467, USA.
Chelsea HopkinsDepartment of Cell Biology and Human Anatomy, University of California Davis, Sacramento, CA, 95817, USA.
Jaymin UpadhyayDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Paul M WehnG Protein Therapeutics, 3160 Porter Dr. Suite 250, Palo Alto, CA, 94304, USA.
Kelly L WentworthDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Francisco. 513 Parnassus Ave., HSE 901, San Francisco, CA, 94143-0794, USA.
Yingzi YangDepartment of Developmental Biology, Harvard School of Dental Medicine, Harvard Stem Cell Institute, 188 Longwood Ave, Boston, MA, 02115, USA.
Xuefeng ZhaoState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.
Edward C HsiaoDivision of Endocrinology and Metabolism, Department of Medicine, The Institute for Human Genetics; and the Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, CA, 94143, USA. edward.Hsiao@ucsf.edu.
Mara RiminucciDepartment of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, 00161, Italy. mara.riminucci@uniroma1.it.

Funding

Gas-Hedgehog signaling in intramembranous bone formation and expansionR01DE025866 · NIDCR · HARVARD MEDICAL SCHOOL · PI Yingzi Yang · 2016 to 2026
$5.3M
NIDCR NIH HHS R01 DE025866
6 · The paper itself

Abstract

Fibrous dysplasia/McCune Albright syndrome (FD/MAS) is a rare genetic disease caused by postzygotic activating variants in the GNAS gene, encoding the α subunit of stimulatory G protein (Gα

Indexed as

Fibrous Dysplasia, PolyostoticAnimalsChromograninsGTP-Binding Protein alpha Subunits, GsHumansTranslational Research, BiomedicalChromograninsGNAS protein, humanGTP-Binding Protein alpha Subunits, GsBone remodelingGNASMouse modelsOsteoclastogenesisOsteogenesisRANKLRare diseaseSkeletal stem cell

Identifiers

PMID40781626
PMCPMC12335126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.