ArticleBMC microbiology2025
16S rDNA sequencing and targeted metabolomics reveal rhizosphere microbial diversity and flavonoid dynamics in Scutellaria baicalensis Georgi.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Rhizosphere bacterial and fungal community structure varies among field-grownFrontiers in microbiology · 2026Article
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Abstract
aimsScutellaria baicalensis Georgi is a commonly utilized bulk Chinese medicinal material in China. In clinical practice, it is often divided into ZiQin and KuQin according to their growth years and different medicinal purposes. Extensive herbal research and pharmacological studies have demonstrated distinct effects of ZiQin and KuQin. Therefore, we collected HuangQin along with its rhizosphere soils at different growth stages to investigate the impact of soil microorganisms on flavonoid synthesis in HuangQin.
methodsIn this study, high-throughput sequencing and UPLC-MS/MS-based metabolomics method were employed for the analysis of 16S rDNA sequences in HuangQin rhizosphere soil samples and metabolic profiling of HuangQin, respectively.
resultsThe results revealed that the number of operational taxonomic units (OTUs) for the four years were 7594, 10,227, 10,280, and 9796, respectively. Furthermore, an extended cultivation period led to a gradual decrease in the abundance of Pseudarthrobacter, Achromobacter and other beneficial bacteria. In addition to this, a total of 552 secondary metabolites were identified in the metabolome. The analysis revealed that 56 components could be successfully mapped to the KEGG database, encompassing five distinct metabolic pathways: isoflavonoid biosynthesis, metabolic pathways, biosynthesis of secondary metabolites, flavonoid biosynthesis and flavone and flavanol biosynthesis. Correlation analysis between soil physicochemical properties and differential microorganisms demonstrated significant associations: Pseudarthrobacter exhibited strong correlations with TN (total nitrogen), AN (ammonium nitrogen), AK (available potassium), and NH
conclusionThe results suggest that flavonoid accumulation in S. baicalensis may be influenced by soil physicochemical properties and rhizosphere microorganisms, providing a valuable basis for future research on optimizing cultivation practices.
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