Evidence map›Paper›PMID 40781519›Full record

ArticleScientific reports2025

Reproducible Ala-Gly oligomerization catalyzed by the natural Borate colemanite in prebiotic conditions.

Isabella Rimoldi, Giorgio Facchetti, Lucia Feni, Giacomo Diego Gatta, Paolo Lotti, Silvia Rizzato, Michael S Christodoulou, Lucia Silvestrini, Leonardo Lo Presti

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabella RimoldiDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Via Venezian 21, 20133, Milano, Italy.
Giorgio FacchettiDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Via Venezian 21, 20133, Milano, Italy.
Lucia FeniDepartment of Pharmaceutical Sciences, Università degli Studi di Milano, Via Venezian 21, 20133, Milano, Italy.
Giacomo Diego GattaDepartment of Earth Sciences "Ardito Desio", Università degli Studi di Milano, Via Botticelli 23, 20133, Milan, Italy.
Paolo LottiDepartment of Earth Sciences "Ardito Desio", Università degli Studi di Milano, Via Botticelli 23, 20133, Milan, Italy.
Silvia RizzatoDepartment of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy.
Michael S ChristodoulouDepartment of Food, Environmental and Nutritional Sciences, Università degli Studi di Milano, Via Celoria 2, 20133, Milan, Italy.
Lucia SilvestriniDG for Life, Lita-Ghirlanda square, 20013, Magenta, MI, Italy.
Leonardo Lo PrestiDepartment of Chemistry, Università degli Studi di Milano, Via Golgi 19, 20133, Milan, Italy. leonardo.lopresti@unimi.it.

Funding

Università degli Studi di Milano SoE SEED 2020 - 1080
6 · The paper itself

Abstract

The abiogenesis of complex peptides is a yet unsolved problem concerning the origin of life, as it is unclear how specific amino acid sequences could be formed in the absence of a regulation mechanism. Crystalline minerals could have provided template scaffolds to sustain replicable oligomerization processes. We demonstrate that the natural organophilic borate colemanite, CaB

Indexed as

AlanineBoratesGlycineAmino Acid SequenceCatalysisOrigin of LifePeptidesAlanineBoratesGlycinePeptides

Identifiers

PMID40781519
PMCPMC12334578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.