ReviewMolecular diversity2026
An insight into the synthetic routes for N-arylation of morpholine using metal-catalyzed and metal-free methods.
Review in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
N-Aryl morpholines are valuable heterocyclic scaffolds with significant applications in medicinal and materials chemistry. The efficient construction of the C-N bond between morpholine and aryl units remains a central challenge in organic synthesis. Transition metal-based catalysis, often supported with ligands, allows the selective and efficient production of N-aryl bonds. In parallel, metal-free strategies including microwave-assisted synthesis, quantum dot-mediated reactions, Lewis acid catalysis, and photo-catalysis offer sustainable alternatives. These reactions are discussed in light of their substrate scopes, mechanistic profiles, and reaction efficiencies, highlighting the continuous evolution and optimization essential for further research. Collectively, this review aims to provide a state-of-the-art perspective on the synthesis of N-arylation of morpholine reported in 2021-2025.
Indexed as
Identifiers
40781508What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.