Evidence map›Paper›PMID 40781464›Full record

ArticleScientific reports2025

Exposotypes in psychotic disorders.

Walid Yassin, Bryan Kromenacker, James B Green, Carol A Tamminga, Elisabetta C Del Re, Pegah Seif, Cuihua Xia, Ney Alliey-Rodriguez, Elliot S Gershon, Brett A Clementz and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Walid YassinBeth Israel Deaconess Medical Center, Boston, MA, U.S.. walid.yassin00@gmail.com.
Bryan KromenackerDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX, U.S.
James B GreenBeth Israel Deaconess Medical Center, Boston, MA, U.S.
Carol A TammingaDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX, U.S.
Elisabetta C Del ReBeth Israel Deaconess Medical Center, Boston, MA, U.S.
Pegah SeifBeth Israel Deaconess Medical Center, Boston, MA, U.S.
Cuihua XiaDepartments of Psychiatry and Human Genetics, University of Chicago, Chicago, IL, U.S.
Ney Alliey-RodriguezDepartments of Psychiatry and Human Genetics, University of Chicago, Chicago, IL, U.S.
Elliot S GershonDepartments of Psychiatry and Human Genetics, University of Chicago, Chicago, IL, U.S.
Brett A ClementzDepartments of Psychology and Neuroscience, University of Georgia, Athens, GA, Georgia.
Godfrey D PearlsonDepartments of Psychiatry and Neuroscience, Yale University, New Haven, CT, U.S.
Sarah K KeedyDepartments of Psychiatry and Human Genetics, University of Chicago, Chicago, IL, U.S.
Elena I IvlevaDepartment of Psychiatry, UT Southwestern Medical Center, Dallas, TX, U.S.
Scott Kristian HillDepartments of Psychiatry and Human Genetics, University of Chicago, Chicago, IL, U.S.
Jennifer E McDowellDepartments of Psychology and Neuroscience, University of Georgia, Athens, GA, Georgia.
Matcheri S KeshavanBeth Israel Deaconess Medical Center, Boston, MA, U.S.. mkeshava@bidmc.harvard.edu.

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Stability of Biotypes: a Longitudinal Evaluation (STABLE)R01MH103368 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S, KEEDY, SARAH K · 2015 to 2019
$4.5M
5/5 BIPOLAR-SCHIZOPHRENIA NETWORK FOR INTERMEDIATE PHENOTYPES (B-SNIP) - Resubmission - 1R01MH103366 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A, GIBBONS, ROBERT D · 2015 to 2019
$3.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1M
Enhancing Cognition in SchizophreniaK23MH072767 · NIMH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HILL, SCOT KRISTIAN · 2006 to 2010
$794k
Identification of Distinct Biotypes in Clinical High Risk for Psychosis State Using Objective Brain-Based BiomarkersR21MH133001 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI YASSINE, WALID · 2023 to 2024
$346k
NIMH NIH HHS K23 MH072767NIMH NIH HHS MH-072767NIMH NIH HHS MH-077851NIMH NIH HHS MH-077945NIMH NIH HHS MH-078113NIMH NIH HHS MH-103366NIMH NIH HHS MH-103368NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH103366NIMH NIH HHS R01 MH103368NIMH NIH HHS R21 MH133001NIMH NIH HHS R21MH133001
6 · The paper itself

Abstract

Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared to the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), and socioeconomic status (SES) significantly affect psychotic disorder symptoms. This study applied an agnostic clustering approach to identify exposome clusters "Exposotypes (ETs)" and examine their relationship with clinical, cognitive, and functional outcomes. Using data from individuals with psychotic disorders (n = 1,350), and controls (n = 623), we assessed the relationship between the exposotypes and outcomes. Four exposotypes were identified: ET1 characterized by high CHT and SU; ET2, high CHT; ET3, high SU; ET4, low exposure. Compared to ET4, ET1 demonstrated higher positive and general symptoms, anxiety, depression, impulsivity, and mania; ET2 had higher anxiety, depression, and impulsivity; ET3 had better cognitive and functional outcomes with lower negative symptoms. Intracranial volume was largest in ET3, and smallest in ET2. No group differences in schizophrenia polygenic risk scores were found. The age of onset was 5 years earlier in ET1 than in ET4. These findings provide insight into the complex etiological interplay between trauma, and SU, as well as their unique effects on clinical symptoms, cognition, neurobiology, genetic risk, and functioning.

Indexed as

Psychotic DisordersAdultAdverse Childhood ExperiencesFemaleHumansMaleMiddle AgedRisk FactorsSchizophreniaSocial ClassSubstance-Related DisordersYoung AdultChildhood traumaCognitive functionMachine learningPsychotic disordersSocioeconomic statusSubstance use

Identifiers

PMID40781464
PMCPMC12334662

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.