ArticleScientific reports2025
Hemoglobin and mean platelet volume abnormalities in children exposed to heavy metals and metalloids in a pilot biomonitoring study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Children are particularly vulnerable to the toxic effects of environmental exposure to heavy metals and metalloids (HM/MTs), which can impact red blood cells (RBCs) and platelets. This study aimed to evaluate the relationship between urinary levels of 19 HM/MTs and RBCs and platelet-related hematologic parameters in school-aged children residing in the central western state of Colima, Mexico. A cross-sectional pilot biomonitoring study was conducted, and 91 participants were enrolled. Multiple linear regression models were used to calculate regression coefficients ([Formula: see text]) and 95% confidence intervals. After adjusting for sex, age, nutritional status, and locality of residence, tin was found to be negatively correlated with red cell distribution width ([Formula: see text] = - 0.06, 95% CI - 0.11 to - 0.01). Additionally, each unit increase in urinary lead levels was associated with a 0.6% increase in mean corpuscular hemoglobin ([Formula: see text] = 0.006, 95% CI 0.002 to 0.010). Similarly, each unit increase in tellurium levels was associated with a 55% increase in mean platelet volume ([Formula: see text] = 0.55, 95% CI 0.08 to 1.02). These results suggest that environmental exposure to HM/MTs may be related to alterations in some of the evaluated hematologic parameters in the analyzed school-aged children. Further research, including larger sample sizes and longitudinal studies, is needed to reduce environmental health risks in this vulnerable population.
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