Evidence map›Paper›PMID 40781450›Full record

ArticleBiomolecular NMR assignments2025

Rodolpho do Aido-Machado, Nicola J Baxter, Michelle L Rowe, Manoj B Pohare, Srdjan Vitovski, Jon R Sayers, Jonathan P Waltho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rodolpho do Aido-MachadoDivision of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.ORCID https://orcid.org/0000-0001-6331-4216
Nicola J BaxterSchool of Biosciences, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.ORCID https://orcid.org/0009-0000-8292-7800
Michelle L RoweSchool of Biosciences, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK.ORCID https://orcid.org/0000-0002-9237-1540
Manoj B PohareDivision of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.ORCID https://orcid.org/0000-0003-2272-9946
Srdjan VitovskiDivision of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.ORCID https://orcid.org/0000-0001-6738-6647
Jon R SayersDivision of Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.ORCID https://orcid.org/0000-0002-5082-1443
Jonathan P WalthoSchool of Biosciences, The University of Sheffield, Firth Court, Western Bank, Sheffield, S10 2TN, UK. j.waltho@sheffield.ac.uk.ORCID https://orcid.org/0000-0002-7402-5492

Funding

Biotechnology and Biological Sciences Research Council BB/S007965/1Florey Institute AMR Research Capital Funding NIHR200636Gates Foundation INV-040070
6 · The paper itself

Abstract

Flap endonuclease (FEN) enzymes are a group of metallonucleases that have essential roles in DNA repair and the maintenance of genomic resilience. They catalyse hydrolytic cleavage of a phosphodiester bond to remove 5'-flaps present on double-stranded DNA molecules formed during DNA replication. FEN locates a target scissile bond through the structural recognition of a pronounced bend in the double-stranded DNA substrate along with the presence of both a 5'-flap and a 1-nucleotide 3'-flap. FEN enzymes share a common structural architecture and are functionally conserved across all living organisms. In this work, we report the

Indexed as

Flap EndonucleasesNuclear Magnetic Resonance, BiomolecularPlasmodium falciparumNitrogen IsotopesFlap EndonucleasesNitrogen-15Nitrogen IsotopesBackbone resonance assignmentEarly-stage drug discoveryFlap endonucleasePlasmodium falciparumTransverse relaxation optimised spectroscopy

Identifiers

PMID40781450
PMCPMC12513906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.