ArticleAnalytical and bioanalytical chemistry2025
A fluorescent biosensor based on glucose oxidase-DNAzyme/substrate complex synergy for salivary glucose monitoring.
Article in Analytical and bioanalytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Combined Use of Microwave Sensing Technologies and Artificial Intelligence for Biomedical Monitoring and Imaging.Biosensors · 2026Review
- Metal surface-triggered DNAzyme catalysis for efficient DNA cleavage.Communications chemistry · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
Non-invasive glucose sensing technology exhibits significant clinical potential for continuous diabetes monitoring and early screening in high-risk populations. Herein, we developed a modular fluorescent biosensor for salivary glucose monitoring through synergistic integration of a detection module (glucose oxidase) and a signal transduction module (PL DNAzyme-substrate complex). The sensing system employs a fluorophore/quencher pair-modified PL DNAzyme-substrate complex as a fluorescence switching element. Experimental results showed a linear detection range from 40 nM to 1.0 mM with a detection limit of 4.3 nM, demonstrating a 1163-fold improvement in sensitivity compared with the previous version. The biosensor exhibited excellent specificity and stability. It was used to detect 2-h postprandial saliva samples from 15 participants (mean glucose concentration: 53.7 ± 19.5 μM), and its extended functionality was demonstrated through continuous daily monitoring of three participants and 14-day consecutive tracking tests, which successfully captured temporal glucose fluctuations. This work presents a fluorescence-based platform for non-invasive salivary glucose monitoring, while its modular architecture provides a versatile framework for future performance optimization through component substitution.
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