Evidence map›Paper›PMID 40781336›Full record

Observational studyItalian journal of pediatrics2025

Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine.

Cecilia Lugarà, Domenico Corica, Giorgia Pepe, Maria Francesca Messina, Mariella Valenzise, Giuseppina Zirilli, Letteria Anna Morabito, Alessandra Li Pomi, Malgorzata Gabriela Wasniewska, Tommaso Aversa

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cecilia LugaràDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Domenico CoricaDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Giorgia PepeDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Maria Francesca MessinaDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Mariella ValenziseDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Giuseppina ZirilliDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Letteria Anna MorabitoPediatric Unit, "G. Martino" University Hospital, Via Consolare Valeria, Messina, 98124, Italy.
Alessandra Li PomiDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Malgorzata Gabriela WasniewskaDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy.
Tommaso AversaDepartment of Human Pathology of Adulthood and Childhood, University of Messina, Via Consolare Valeria, Messina, 98124, Italy. tommaso.aversa@unime.it.ORCID http://orcid.org/0000-0002-1754-6822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChildren with congenital hypothyroidism (CH) are at increased risk of developing childhood obesity. Moreover, an adiposity rebound (AR) that occur early is strongly linked with future obesity. The aims of our study were to explore the timing of AR, to identify factors affecting AR and correlation between age and body mass index (BMI) at AR and BMI at eight years of age in children with CH.

methodsA retrospective, observational study was conducted on Caucasian children with CH. For each child, BMI growth curve was constructed, AR was identified and compared with the Italian national and regional references.

resultsSixty-nine patients (44 females) were recruited. The age at AR was 3.4 ± 1.2 vs. 4.5 years of the comparison population (p < 0.001) in females and 3.4 ± 1.4 vs. 5.0 years of the comparison population (p < 0.001) in males with CH. Age at AR showed a significant negative correlation with BMI at 8 years (r = − 0.274, p < 0.039). BMI at AR and BMI at 8 years of age correlated positively (r = 0.460, p < 0.001). The prevalence of obesity/overweight at 8 years of age was 30%. BMI at 8 years of age was 22.4 ± 1.8 kg/m2 in overweight/obese subgroup and 16.9 ± 1.8 kg/m2 in normal BMI subgroup (P 0.001).

conclusionChildren with CH showed earlier AR compared to Italian national references. The higher risk of obesity in patients with early AR is supported by the association between age, BMI at AR, and BMI at eight years.

Indexed as

AdiposityCongenital HypothyroidismPediatric ObesityThyroxineBody Mass IndexChildChild, PreschoolFemaleHumansInfant, NewbornItalyMaleNeonatal ScreeningRetrospective StudiesThyroxineAdiposity reboundChildhood obesityCongenital hypothyroidismEarly adiposity reboundLevothyroxineNeonatal screening

Identifiers

PMID40781336
PMCPMC12333145

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.