ArticleRadiation oncology (London, England)2025
From standardized to individualized margins for online adaptive tumor dose escalation in rectal cancer.
Article in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo determine the impact of tumor characteristics such as tumor volume, circumference and location in the rectum on intrafraction motion during dose-escalated MRI-guided radiotherapy of rectal cancer and to explore the potential of PTV margin individualization.
methodsSeventy-seven rectal cancer patients, treated with short course radiotherapy (SCRT) on a 1.5T MR-Linac, were included in the study. For all five treatment fractions per patient, the GTV of the primary tumor was manually delineated on T2-weighted images acquired for online plan adaptation (MRI
resultsIntrafraction motion was correlated with tumor location with larger displacement in Anterior-Posterior (p = 0.001) and Cranial-Caudal (CC; p = 0.043) direction for caudal tumors compared to proximal tumors (lower border starting > 5 cm from anorectal junction). For tumor volume, a significant (p = 0.049), but small association with Left-Right motion was found, with larger tumors exhibiting larger motion. PTV margins required for the full cohort were 2.8 mm LR, 6.3 mm AP, 2.2 mm cranial and 5.6 mm caudal. Individualizing on tumor location resulted in AP margin of 3.5 mm for proximal rectal tumors and 6.7 mm for distal rectal tumors. Margins in CC direction were 3.2 mm for proximal rectal tumors and asymmetrically 2.0 mm cranial and 6.0 mm caudal for distal rectal tumors.
conclusionOur study demonstrated that distance to anorectal junction significantly influenced the magnitude and direction of the intrafraction motion of rectal cancer patients receiving SCRT, with distal tumors showing larger motion in the AP and CC directions. For proximal rectal tumors, the margin could be decreased in AP and CC direction.
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