ArticleBMC medicine2025
Sleep, physical activity, sedentary behavior, and risk of cataract: a cross-sectional and prospective study from UK Biobank.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity and the risk of cataract and age-related macular degeneration: a systematic review and meta-analysis of cohort studies.BMC ophthalmology · 2026Pooled it
- Does adherence to Canadian 24-Hour Movement Guidelines reduce all-cause mortality in patients with chronic kidney disease?Medicine · 2026Article
- Accelerometer-Derived Moderate-to-Vigorous Physical Activity and the Risk of Four Common Vision-Threatening Ocular Diseases.Translational vision science & technology · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
backgroundCataract is a leading cause of visual impairment globally. Although daily behaviors such as sleep, physical activity (PA), and sedentary behavior (SB) have been associated with cataract risk, the evidence remains controversial and uncertain. This study aimed to examine the independent and combined effects of sleep, PA, and SB on cataract risk using data from the UK Biobank.
methodsThe cross-sectional analyses included 440,645 participants from the UK Biobank with complete data on sleep, PA, and SB. For the longitudinal analyses, a subset of 426,540 participants without cataract at baseline was included. Cataract cases were identified through hospital inpatient records and self-reported data. Baseline data on sleep, PA, and SB were collected via touchscreen questionnaires. Logistic regression and Cox proportional hazards models were used to examine the independent and synergistic associations between sleep, PA, SB, and cataract.
resultsIn the cross-sectional analyses, 440,645 participants were evaluated (54.0% female; mean [SD] age, 56.5 [8.1] years), of whom 14,105 (3.2%) had cataract. Significant associations were found between poor sleep (OR, 1.35; 95% CI, 1.23-1.48), low PA (OR, 1.06; 95% CI, 1.01-1.11), and cataract. Longitudinal analyses included 426,540 participants (53.9% female; mean [SD] age, 56.3 [8.1] years). During a mean follow-up period of 10.8 years, 55,658 incident cataract cases were recorded. Poor sleep (HR, 1.14; 95% CI, 1.08-1.19), low PA (HR, 1.05; 95% CI, 1.02-1.07), and high SB (HR, 1.08; 95% CI, 1.06-1.11) were correlated with increased cataract risk. The combination of poor sleep, low PA, and high SB further elevated the risk, with the highest odds in cross-sectional (OR, 1.73; 95% CI, 1.37-2.15) and prospective (HR, 1.37; 95% CI, 1.21-1.55) analyses. Replacing 1 h/day of SB time with an equal time spent in total PA and sleep was associated with a 1.7% and 2.7% decreased risk of cataract, respectively.
conclusionsPoor sleep, low PA, and high SB are independently and jointly associated with an increased risk of cataract. Modifying these behaviors, either individually or in combination, can effectively mitigate the risk of cataract.
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