ArticleBMC anesthesiology2025
Irradiated red blood cell transfusion is associated with an increased incidence of deep vein thrombosis in trauma patients: a cohort study.
Article in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGamma-ray irradiation accelerates the release of red blood cell (RBC)-derived microparticles with procoagulant function, and further promotes the formation of microthrombosis. The use of irradiated RBCs in trauma patients is usually not prohibited. At present, the association that irradiated RBC transfusion and incidence of deep vein thrombosis (DVT) remains unclear.
methodsThis retrospective cohort study included 251 trauma patients between January 2019 and April 2023 at the Second Affiliated Hospital of Chongqing Medical University. The cohort included 147 patients who were only transfused with nonirradiated RBCs (nonirradiation group) and 104 patients who were transfused with irradiated RBCs with or without nonirradiated RBCs (irradiation group). Univariate and multivariate logistic regression analysis was used to analyze the risk factors for DVT.
resultsThe incidence of DVT was higher in the irradiation group than in the nonirradiation group (38.5% vs. 22.4%, p = 0.006), and irradiated RBC transfusion was associated with an increased incidence of DVT in the univariate analysis (OR 2.16, 95% CI: 1.25-3.77, p = 0.006). After adjusting for potential confounders by multivariate analysis, irradiated RBC transfusion appeared to be a risk factor for DVT (OR 2.48, 95% CI: 1.34-4.65, p = 0.004). Subgroup analysis revealed that the median storage days of irradiated RBCs and the percentage of irradiated RBCs in total transfused RBCs were positively association with the incidence of DVT (OR 2.95 and 3.19, respectively, both p < 0.05).
conclusionIrradiated RBC transfusion was associated with an increased incidence of DVT in trauma patients. Irradiated RBC transfusion in trauma patients might need to be reconsidered.
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