ArticleBMC infectious diseases2025
Drug resistance among students with pulmonary tuberculosis: a study based on screening in Henan, China.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Molecular epidemiology of drug-resistant tuberculosis in Jiangxi Province, China, 2022-2023.Global health & medicine · 2025Article
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12 authors.
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Abstract
backgroundTuberculosis (TB) can easily spread among students and can lead to an outbreak once there is an infection in a school. Outbreaks of drug-resistant TB (DR-TB) in schools have occasionally been reported, but the profile of DR-TB in students in a province has rarely been described. This study was conducted to determine the prevalence of DR-TB and factors associated with it in students in Henan Province, China.
methodsWe retrospectively reviewed the data of 3527 pulmonary TB patients among students with culture-confirmed Mycobacterium tuberculosis (M.tb) isolates collected from the Tuberculosis Information Management System of the China Disease Prevention and Control Information System from 2015 to 2021. Prevalence of DR-TB was analyzed. Comparisons between categorical variables were analyzed using the chi-square test or Fisher's exact test as appropriate. Logistic regression models were used to identify the factors associated with DR-TB.
resultsAny DR-, RR (rifampin resistance)- and MDR (multi-drug resistance) -TB rates in students were 10.46%, 7.91% and 6.10%, respectively. And they all showed a downward trend from 2015 to 2021 (p < 0.001). Previously treated cases were 7.30 (95% CI: 5.30, 10.05), 8.60 (95% CI: 6.14,12.14) and 9.43 (95% CI: 6.64,13.40) times more likely than the new cases to be diagnosed with Any DR-TB, RR-TB and MDR-TB, respectively. Patients from schools in the western region of Henan had greater odds of having Any DR- (AOR = 2.06, 95% CI: 1.31, 3.24), RR- (AOR = 2.81, 95% CI: 1.66, 4.76) and MDR-TB (AOR = 2.07, 95% CI: 1.13, 3.80) than those from schools in the northern region. Males had a 1.40-fold (95% CI: 1.11, 1.78), 1.34-fold (95% CI: 1.02, 1.75) greater likelihood of being diagnosed with Any DR- and RR-TB, respectively. The risk of being diagnosed with MDR-TB was 1.42 (95% CI: 1.00, 2.02) times greater in students migrant between prefectures of the province than in the locals.
conclusionThe prevalence of DR-TB among students with PTB in Henan, China, significantly decreased from 2015 to 2021. Previous treated cases and those in west-region schools in Henan were at greater risk of being diagnosed with Any DR-, RR- and MDR-TB. In addition, males were more likely to be diagnosed with Any DR- and RR-TB. It requires further study that whether those who migrated between prefectures of the province were more likely to be diagnosed with MDR-TB.
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