Evidence map›Paper›PMID 40781252›Full record

ArticleNPJ Parkinson's disease2025

Towards scalable screening for the early detection of Parkinson's disease: validation of an iPad-based eye movement assessment system against a clinical-grade eye tracker.

Jamie Koerner, Erin Zou, Jessica A Karl, Cynthia Poon, Leo Verhagen Metman, Charles G Sodini, Vivienne Sze, Fabian J David, Thomas Heldt

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jamie KoernerDepartment of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.
Erin ZouChicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, USA.
Jessica A KarlDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Cynthia PoonDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Leo Verhagen MetmanDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Charles G SodiniDepartment of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.
Vivienne SzeDepartment of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA.
Fabian J David *Department of Physical Therapy and Human Movement Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Thomas Heldt *Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA. thomas@mit.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection and monitoring of Parkinson's disease (PD) remain challenging, highlighting the need for accessible, cost-effective tools. Saccadic eye movement abnormalities are promising noninvasive biomarkers for PD screening and monitoring. Here, we present an iPad-based system that uses a deep learning algorithm to extract saccade metrics and validate these metrics against the clinical-grade EyeLink 1000 Plus. Twenty-five participants (10 with PD, 15 controls) completed pro-saccade, anti-saccade, memory-guided-saccade, and self-generated-saccade tasks. Relative to the EyeLink, the iPad system achieved average subject-level errors of 2 ms for latency and 0.7

Identifiers

PMID40781252
PMCPMC12334683

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.