Evidence map›Paper›PMID 40781241›Full record

ArticleNPJ breast cancer2025

Race-related host and microbe transcriptomic signatures in triple-negative breast cancer.

Roshan Kumar, Susan Duyar-Ayerdi, Aishwarya Sundaresan, Vinodh Srinivasasainagendra, Chandra Sekhar Pedamallu, Michael Behring, Darshan Shimoga Chandrashekar, Isam-Eldin Eltoum, Sooryanarayana Varambally, Hemant K Tiwari and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Roshan KumarDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.
Susan Duyar-AyerdiDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA.
Aishwarya SundaresanDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Vinodh SrinivasasainagendraDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Chandra Sekhar PedamalluExcelra, Boston, MA, USA.
Michael BehringDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Darshan Shimoga ChandrashekarDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Isam-Eldin EltoumDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sooryanarayana VaramballyDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Hemant K TiwariDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Sadeep ShresthaDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Paul L AuerMedical College of Wisconsin Cancer Center, Milwaukee, WI, USA.
Lubna N ChaudharyDepartment of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.
John R KirbyDepartment of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA.
Clayton YatesDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Upender ManneDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA. upendermanne@uabmc.edu.
Akinyemi I OjesinaDepartment of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA. aojesina@mcw.edu.

Funding

Molecular Markers for Tumors Associated with Extrachromosomal HPVR01CA279323 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Akinyemi Ifedapo Ojesina · 2024 to 2026
$1.7M
Avon Foundation for Women 02-2013-023NCI NIH HHS R01 CA279323NIH HHS 3U54CA118948-14S2NIH HHS 5U54CA118623NIH HHS 5U54CA118948
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) shows racial disparities, with higher incidence in women of African ancestry (AA) compared to European ancestry (EA). Meta-transcriptomic analysis of TNBC tumor tissues from AA (n = 17) and EA (n = 19) subjects revealed distinct microbial landscapes. Hierarchical clustering based on microbial transcripts separated samples into two groups predominantly defined by racial ancestry. Bacterial genera including Hafnia and Cedecea were more abundant in AA tumors, while Erwinia was higher in EA tumors. Cellular composition analysis by xCell revealed differences in immune cell populations, with AA tumors having higher Th1 cell abundance and EA tumors containing higher macrophage M2 cell abundance. Nonetheless, AA women with high M2 abundance experienced poorer disease-free survival (DFS) than EA women. Integrative analyses revealed that high expression of human SPDYE2B gene was associated with Hafnia abundance and decreased DFS, highlighting complex host-microbe interactions in TNBC patients.

Identifiers

PMID40781241
PMCPMC12334597

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