Evidence map›Paper›PMID 40781236›Full record

ArticleTranslational psychiatry2025

Entorhinal cortex layer III Adgrl2 expression controls topographical circuit connectivity required for sequence learning.

Jordan D Donohue, Crisylle Blanton, Anna Chen, Amna Ahmad, Elizabeth D Liu, Lisette Saab, Rajbir Kaur, Woojin Yang, Garret R Anderson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jordan D DonohueDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.ORCID http://orcid.org/0000-0003-2997-5525
Crisylle BlantonDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.
Anna ChenDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.
Amna AhmadDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.
Elizabeth D LiuDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.ORCID http://orcid.org/0000-0001-9719-4160
Lisette SaabDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.
Rajbir KaurDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.
Woojin YangDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA.
Garret R AndersonDepartment of Molecular, Cell, and Systems Biology; University of California - Riverside, Riverside, CA, 92521, USA. garret.anderson@ucr.edu.ORCID http://orcid.org/0000-0003-4866-4255

Funding

Whitehall Foundation (Whitehall Foundation, Inc.) 2018-08-01
6 · The paper itself

Abstract

The entorhinal cortex and hippocampus are interconnected brain regions required for episodic learning and memory. For this functional encoding, correct assembly of specific synaptic connections across this circuit is critical during development. To guide the connection specificity between neurons, a multitude of circuit building molecular components are required, including the latrophilin family of adhesion G protein-coupled receptors (Lphn1-3; gene symbols Adgrl1-3). Within this genetic family, Adgrl2 exhibits a unique topographical and cell-type specific expression patterning in the entorhinal cortex and hippocampus that mirrors connectivity. To investigate the role of Adgrl2 in a cell-type specific fashion for this circuit, we here created a transgenic mouse (Adgrl2

Indexed as

Entorhinal CortexHippocampusLearningReceptors, G-Protein-CoupledAnimalsMaleMiceMice, TransgenicNeural PathwaysNeuronsReceptors, G-Protein-Coupled

Identifiers

PMID40781236
PMCPMC12334705

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.